Role of the MexAB-OprM Efflux Pump of Pseudomonas aeruginosa in Tolerance to Tea Tree ( Melaleuca alternifolia ) Oil and Its Monoterpene Components Terpinen-4-ol, 1,8-Cineole, and a-Terpineol

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Abstract

Using a series of efflux mutants of Pseudomonas aeruginosa, the MexAB-OprM pump was identified as contributing to this organism's tolerance to the antimicrobial agent tea tree (Melaleuca alternifolia) oil and its monoterpene components terpinen-4-ol, 1,8-cineole, and ɑ-terpineol. These data show that a multidrug efflux system of P. aeruginosa can extrude monoterpenes and related alcohols.
Original languageEnglish
Pages (from-to)1932-1935
JournalApplied and Environmental Microbiology
Volume74
Issue number6
DOIs
Publication statusPublished - 2008

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