Role of substrate biomechanics in controlling (stem) cell fate: Implications in regenerative medicine

Laura Macri-Pellizzeri, Elena M. De-Juan-Pardo, Felipe Prosper, Beatriz Pelacho

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Tissue-specific stem cells reside in a specialized environment known as niche. The niche plays a central role in the regulation of cell behaviour and, through the concerted action of soluble molecules, supportive somatic cells, and extracellular matrix components, directs stem cells to proliferate, differentiate, or remain quiescent. Great efforts have been done to decompose and separately analyse the contribution of these cues in the in vivo environment. Specifically, the mechanical properties of the extracellular matrix influence many aspects of cell behaviour, including self-renewal and differentiation. Deciphering the role of biomechanics could thereby provide important insights to control the stem cells responses in a more effective way with the aim to promote their therapeutic potential. In this review, we provide a wide overview of the effect that the microenvironment stiffness exerts on the control of cell behaviour with a particular focus on the induction of stem cells differentiation. We also describe the process of mechanotransduction and the molecular effectors involved. Finally, we critically discuss the potential involvement of tissue biomechanics in the design of novel tissue engineering strategies.

Original languageEnglish
Pages (from-to)1012-1019
Number of pages8
JournalJournal of Tissue Engineering and Regenerative Medicine
Volume12
Issue number4
DOIs
Publication statusPublished - Apr 2018
Externally publishedYes

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