Abstract
Bidirectional transport of four novel antimalarial compounds was determined using Caco-2 cell monolayers. P glycoprotein-mediated efflux was greatest for pyronaridine (5 to 20 mu M) and low for naphthoquine (5 mu M). With 20 mu M naphthoquine, net efflux was blocked, suggesting saturation of the transporter. Piperaquine and dihydroartemisinin were not transported by the system.
| Original language | English |
|---|---|
| Pages (from-to) | 3504-3506 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 50 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2006 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
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