Role of P Glycoprotein in Absorption of Novel Antimalarial Drugs

A. Crowe; Kenneth Ilett; H.A. Karunajeewa; K.T. Batty; Timothy Davis

doi:10.1128/AAC.00708-06

Role of P Glycoprotein in Absorption of Novel Antimalarial Drugs

A. Crowe, Kenneth Ilett, H.A. Karunajeewa, K.T. Batty, Timothy Davis

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Bidirectional transport of four novel antimalarial compounds was determined using Caco-2 cell monolayers. P glycoprotein-mediated efflux was greatest for pyronaridine (5 to 20 mu M) and low for naphthoquine (5 mu M). With 20 mu M naphthoquine, net efflux was blocked, suggesting saturation of the transporter. Piperaquine and dihydroartemisinin were not transported by the system.

Original language	English
Pages (from-to)	3504-3506
Journal	Antimicrobial Agents and Chemotherapy
Volume	50
Issue number	10
DOIs	https://doi.org/10.1128/AAC.00708-06
Publication status	Published - 2006

Access to Document

10.1128/AAC.00708-06

Cite this

@article{49f0f80016ab413c8d5c9045ddc59193,

title = "Role of P Glycoprotein in Absorption of Novel Antimalarial Drugs",

abstract = "Bidirectional transport of four novel antimalarial compounds was determined using Caco-2 cell monolayers. P glycoprotein-mediated efflux was greatest for pyronaridine (5 to 20 mu M) and low for naphthoquine (5 mu M). With 20 mu M naphthoquine, net efflux was blocked, suggesting saturation of the transporter. Piperaquine and dihydroartemisinin were not transported by the system.",

author = "A. Crowe and Kenneth Ilett and H.A. Karunajeewa and K.T. Batty and Timothy Davis",

year = "2006",

doi = "10.1128/AAC.00708-06",

language = "English",

volume = "50",

pages = "3504--3506",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "10",

}

TY - JOUR

T1 - Role of P Glycoprotein in Absorption of Novel Antimalarial Drugs

AU - Crowe, A.

AU - Ilett, Kenneth

AU - Karunajeewa, H.A.

AU - Batty, K.T.

AU - Davis, Timothy

PY - 2006

Y1 - 2006

N2 - Bidirectional transport of four novel antimalarial compounds was determined using Caco-2 cell monolayers. P glycoprotein-mediated efflux was greatest for pyronaridine (5 to 20 mu M) and low for naphthoquine (5 mu M). With 20 mu M naphthoquine, net efflux was blocked, suggesting saturation of the transporter. Piperaquine and dihydroartemisinin were not transported by the system.

AB - Bidirectional transport of four novel antimalarial compounds was determined using Caco-2 cell monolayers. P glycoprotein-mediated efflux was greatest for pyronaridine (5 to 20 mu M) and low for naphthoquine (5 mu M). With 20 mu M naphthoquine, net efflux was blocked, suggesting saturation of the transporter. Piperaquine and dihydroartemisinin were not transported by the system.

U2 - 10.1128/AAC.00708-06

DO - 10.1128/AAC.00708-06

M3 - Article

SN - 0066-4804

VL - 50

SP - 3504

EP - 3506

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 10

ER -

Role of P Glycoprotein in Absorption of Novel Antimalarial Drugs

Abstract

Access to Document

Fingerprint

Cite this