Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases

A.A. Momtazi; G. Derosa; P. Maffioli; M. Banach; Amirhossein Sahebkar

doi:10.1007/s40291-016-0202-7

Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases

A.A. Momtazi, G. Derosa, P. Maffioli, M. Banach, Amirhossein Sahebkar

Research output: Contribution to journal › Review article

157 Citations (Scopus)

Abstract

© 2016, Springer International Publishing Switzerland.Curcumin is a bioactive polyphenol occurring in the rhizomes of Curcumalonga. It is well-reputed for its chemopreventive and anticancer properties; however, recent evidence has revealed numerous biological and pharmacological effects of curcumin that are relevant to the treatment of non-cancer diseases. Mechanistically, curcumin exerts its pharmacological effects through anti-inflammatory and antioxidant mechanisms via interaction with different signaling molecules and transcription factors. In addition, epigenetic modulators such as microRNAs (miRs) have emerged as novel targets of curcumin. Curcumin was found to modulate the expression of several pathogenic miRs in brain, ocular, renal, and liver diseases. The present systematic review was conducted to identify miRs that are regulated by curcumin in non-cancer diseases.

Original language	English
Pages (from-to)	335-345
Number of pages	11
Journal	Molecular Diagnosis and Therapy
Volume	20
Issue number	4
DOIs	https://doi.org/10.1007/s40291-016-0202-7
Publication status	Published - 1 Aug 2016

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title = "Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases",

abstract = "{\textcopyright} 2016, Springer International Publishing Switzerland.Curcumin is a bioactive polyphenol occurring in the rhizomes of Curcumalonga. It is well-reputed for its chemopreventive and anticancer properties; however, recent evidence has revealed numerous biological and pharmacological effects of curcumin that are relevant to the treatment of non-cancer diseases. Mechanistically, curcumin exerts its pharmacological effects through anti-inflammatory and antioxidant mechanisms via interaction with different signaling molecules and transcription factors. In addition, epigenetic modulators such as microRNAs (miRs) have emerged as novel targets of curcumin. Curcumin was found to modulate the expression of several pathogenic miRs in brain, ocular, renal, and liver diseases. The present systematic review was conducted to identify miRs that are regulated by curcumin in non-cancer diseases.",

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T1 - Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases

AU - Momtazi, A.A.

AU - Derosa, G.

AU - Maffioli, P.

AU - Banach, M.

AU - Sahebkar, Amirhossein

PY - 2016/8/1

Y1 - 2016/8/1

N2 - © 2016, Springer International Publishing Switzerland.Curcumin is a bioactive polyphenol occurring in the rhizomes of Curcumalonga. It is well-reputed for its chemopreventive and anticancer properties; however, recent evidence has revealed numerous biological and pharmacological effects of curcumin that are relevant to the treatment of non-cancer diseases. Mechanistically, curcumin exerts its pharmacological effects through anti-inflammatory and antioxidant mechanisms via interaction with different signaling molecules and transcription factors. In addition, epigenetic modulators such as microRNAs (miRs) have emerged as novel targets of curcumin. Curcumin was found to modulate the expression of several pathogenic miRs in brain, ocular, renal, and liver diseases. The present systematic review was conducted to identify miRs that are regulated by curcumin in non-cancer diseases.

AB - © 2016, Springer International Publishing Switzerland.Curcumin is a bioactive polyphenol occurring in the rhizomes of Curcumalonga. It is well-reputed for its chemopreventive and anticancer properties; however, recent evidence has revealed numerous biological and pharmacological effects of curcumin that are relevant to the treatment of non-cancer diseases. Mechanistically, curcumin exerts its pharmacological effects through anti-inflammatory and antioxidant mechanisms via interaction with different signaling molecules and transcription factors. In addition, epigenetic modulators such as microRNAs (miRs) have emerged as novel targets of curcumin. Curcumin was found to modulate the expression of several pathogenic miRs in brain, ocular, renal, and liver diseases. The present systematic review was conducted to identify miRs that are regulated by curcumin in non-cancer diseases.

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DO - 10.1007/s40291-016-0202-7

M3 - Review article

C2 - 27241179

SN - 1177-1062

VL - 20

SP - 335

EP - 345

JO - Molecular Diagnosis and Therapy

JF - Molecular Diagnosis and Therapy

IS - 4

ER -

Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases

Abstract

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