Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases

A.A. Momtazi, G. Derosa, P. Maffioli, M. Banach, Amirhossein Sahebkar

    Research output: Contribution to journalReview article

    157 Citations (Scopus)


    © 2016, Springer International Publishing Switzerland.Curcumin is a bioactive polyphenol occurring in the rhizomes of Curcumalonga. It is well-reputed for its chemopreventive and anticancer properties; however, recent evidence has revealed numerous biological and pharmacological effects of curcumin that are relevant to the treatment of non-cancer diseases. Mechanistically, curcumin exerts its pharmacological effects through anti-inflammatory and antioxidant mechanisms via interaction with different signaling molecules and transcription factors. In addition, epigenetic modulators such as microRNAs (miRs) have emerged as novel targets of curcumin. Curcumin was found to modulate the expression of several pathogenic miRs in brain, ocular, renal, and liver diseases. The present systematic review was conducted to identify miRs that are regulated by curcumin in non-cancer diseases.
    Original languageEnglish
    Pages (from-to)335-345
    Number of pages11
    JournalMolecular Diagnosis and Therapy
    Issue number4
    Publication statusPublished - 1 Aug 2016


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