Role of Exercise in NAFLD/NASH: What is the Right Prescription?

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of Review
Non-alcoholic fatty liver disease is the most prevalent liver disease worldwide and is associated with increased mortality risk related to cardiovascular and liver disease. We aim to review the current evidence regarding the role of exercise in non-alcoholic fatty liver disease (NAFLD), which is the current cornerstone of treatment in conjunction with diet.

Recent Findings
Regular moderate- and high-intensity exercise improve intrahepatic steatosis by 2–10% with no significant difference between aerobic and resistance programs. The optimal duration, intensity, and volume required for improvement of non-alcoholic steatohepatitis (NASH) and fibrosis are unknown. Benefits of exercise extend beyond the liver to improve cardiovascular risk profiles, insulin resistance, and obesity, which are all linked directly to NASH.

Summary
Exercise type (aerobic versus resistance), dosage, and duration should be tailored considering age, adherence, and comorbidities and should be combined with specific dietary modifications.
Original languageEnglish
Pages (from-to)356–365
JournalCurrent Hepatology Reports
Volume16
Issue number4
DOIs
Publication statusPublished - 2017

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