Role of cholesterol in regulating apolipoprotein B secretion by the liver

G.R. Thompson, R.P. Naoumova, Gerald Watts

    Research output: Contribution to journalLiterature review

    160 Citations (Scopus)

    Abstract

    The review examines the evidence that the supply of cholesterol available for incorporation into nascent lipoprotein particles exerts a regulatory influence on apolipoprotein (apo) B secretion by the liver. Support for this hypothesis comes both from in vitro experiments and from recent observations in normal subjects and patients with dyslipidemia associated with familial hypercholesterolemia, obesity, noninsulin dependent diabetes mellitus, growth hormone deficiency and cholesteryl ester storage disease. The findings do not negate a role for triglyceride synthesis in determining apoB secretion in very low density lipoprotein, but the inhibitory effects on the latter process of pharmacological blockade of cholesterol synthesis or esterification suggest that it is conditional upon an adequate supply of cholesteryl ester.

    Original languageEnglish
    Pages (from-to)439-447
    JournalJournal of Lipid Research
    Volume37
    Publication statusPublished - Mar 1996

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