Role of attP in Integrase-Mediated Integration of the Shigella Resistance Locus Pathogenicity Island of Shigella flexneri

S.A. Turner, S.N. Luck, Harry Sakellaris, K. Rajakumar, B. Adler

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    The Shigella resistance locus (SRL) pathogenicity island (PAI) in Shigella spp. mediates resistance to streptomycin, ampicillin, chloramphenicol, and tetracycline. It can be excised from the chromosome via site-specific recombination mediated by the P4-related int gene. Here, we show that SRL PAI attP is capable of RecA-independent, site-specific, int-mediated integration into two bacterial tRNA attB sites.
    Original languageEnglish
    Pages (from-to)0066-4804
    JournalAntimicrobial Agents and Chemotherapy
    Volume48
    Issue number3
    DOIs
    Publication statusPublished - 2004

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