TY - JOUR
T1 - Role of attP in Integrase-Mediated Integration of the Shigella Resistance Locus Pathogenicity Island of Shigella flexneri
AU - Turner, S.A.
AU - Luck, S.N.
AU - Sakellaris, Harry
AU - Rajakumar, K.
AU - Adler, B.
PY - 2004
Y1 - 2004
N2 - The Shigella resistance locus (SRL) pathogenicity island (PAI) in Shigella spp. mediates resistance to streptomycin, ampicillin, chloramphenicol, and tetracycline. It can be excised from the chromosome via site-specific recombination mediated by the P4-related int gene. Here, we show that SRL PAI attP is capable of RecA-independent, site-specific, int-mediated integration into two bacterial tRNA attB sites.
AB - The Shigella resistance locus (SRL) pathogenicity island (PAI) in Shigella spp. mediates resistance to streptomycin, ampicillin, chloramphenicol, and tetracycline. It can be excised from the chromosome via site-specific recombination mediated by the P4-related int gene. Here, we show that SRL PAI attP is capable of RecA-independent, site-specific, int-mediated integration into two bacterial tRNA attB sites.
U2 - 10.1128/AAC.48.3.1028-1031.2004
DO - 10.1128/AAC.48.3.1028-1031.2004
M3 - Article
SN - 0066-4804
VL - 48
SP - 66
EP - 4804
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 3
ER -