TY - JOUR
T1 - Robust reconstruction of local optic axis orientation with fiber-based polarization-sensitive optical coherence tomography
AU - Li, Qingyun
AU - Karnowski, Karol
AU - Noble, Peter B.
AU - Cairncross, Alvenia
AU - James, Alan
AU - Villiger, Martin
AU - Sampson, David D.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - It is challenging to recover local optic axis orientation from samples probed with fiber-based polarization-sensitive optical coherence tomography (PS-OCT). In addition to the effect of preceding tissue layers, the transmission through fiber and system elements, and imperfect system alignment, need to be compensated. Here, we present a method to retrieve the required correction factors from measurements with depth-multiplexed PS-OCT, which accurately measures the full Jones matrix. The correction considers both retardation and diattenuation and is applied in the wavenumber domain, preserving the axial resolution of the system. The robustness of the method is validated by measuring a birefringence phantom with a misaligned system. Imaging ex-vivo lamb trachea and human bronchus demonstrates the utility of reconstructing the local optic axis orientation to assess smooth muscle, which is expected to be useful in the assessment of airway smooth muscle thickness in asthma, amongst other fiber-based applications.
AB - It is challenging to recover local optic axis orientation from samples probed with fiber-based polarization-sensitive optical coherence tomography (PS-OCT). In addition to the effect of preceding tissue layers, the transmission through fiber and system elements, and imperfect system alignment, need to be compensated. Here, we present a method to retrieve the required correction factors from measurements with depth-multiplexed PS-OCT, which accurately measures the full Jones matrix. The correction considers both retardation and diattenuation and is applied in the wavenumber domain, preserving the axial resolution of the system. The robustness of the method is validated by measuring a birefringence phantom with a misaligned system. Imaging ex-vivo lamb trachea and human bronchus demonstrates the utility of reconstructing the local optic axis orientation to assess smooth muscle, which is expected to be useful in the assessment of airway smooth muscle thickness in asthma, amongst other fiber-based applications.
UR - http://www.scopus.com/inward/record.url?scp=85056599820&partnerID=8YFLogxK
U2 - 10.1364/BOE.9.005437
DO - 10.1364/BOE.9.005437
M3 - Article
C2 - 30460138
AN - SCOPUS:85056599820
SN - 2156-7085
VL - 9
SP - 5437
EP - 5455
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 11
M1 - 330240
ER -