RNA Processing in Health and Disease

Giulia Rossetti

doi:10.26182/7xe8-dy68

RNA Processing in Health and Disease

Giulia Rossetti

UWA Medical School

Research output: Thesis › Doctoral Thesis

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Abstract

Energy production in eukaryotic cells takes place inside mitochondria, small organelles of bacterial origin specialised in ATP production. Defects in the mitochondrial RNA processing can impair mitochondrial function and consequently energy production. In humans this can lead to severe diseases or predispose to higher risk to develop pathological conditions with age. In this thesis I investigated the effects of altered mitochondrial RNA processing in vivo and its consequences on health. This will contribute to closing the gap in knowledge between the identification of genetic mutations and the manifestation of mitochondrial diseases, which is fundamental to develop effective treatments for these pathologies.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Filipovska, Aleksandra, Supervisor Richman, Tara, Supervisor
Award date	15 May 2020
DOIs	https://doi.org/10.26182/7xe8-dy68
Publication status	Unpublished - 2020

Embargo information

Embargoed from 25/05/2020 to 25/05/2022. Made publicly available on 25/05/2022.

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10.26182/7xe8-dy68

THESIS - DOCTOR OF PHILOSOPHY - ROSSETTI, Giulia - 2020
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Cite this

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AB - Energy production in eukaryotic cells takes place inside mitochondria, small organelles of bacterial origin specialised in ATP production. Defects in the mitochondrial RNA processing can impair mitochondrial function and consequently energy production. In humans this can lead to severe diseases or predispose to higher risk to develop pathological conditions with age. In this thesis I investigated the effects of altered mitochondrial RNA processing in vivo and its consequences on health. This will contribute to closing the gap in knowledge between the identification of genetic mutations and the manifestation of mitochondrial diseases, which is fundamental to develop effective treatments for these pathologies.

KW - mitochondria

KW - gene expression

KW - RNA processing

KW - RNA binding proteins

U2 - 10.26182/7xe8-dy68

DO - 10.26182/7xe8-dy68

M3 - Doctoral Thesis

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RNA Processing in Health and Disease

Abstract

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