RNA Processing in Health and Disease

Giulia Rossetti

Research output: ThesisDoctoral Thesis

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Abstract

Energy production in eukaryotic cells takes place inside mitochondria, small organelles of bacterial origin specialised in ATP production. Defects in the mitochondrial RNA processing can impair mitochondrial function and consequently energy production. In humans this can lead to severe diseases or predispose to higher risk to develop pathological conditions with age. In this thesis I investigated the effects of altered mitochondrial RNA processing in vivo and its consequences on health. This will contribute to closing the gap in knowledge between the identification of genetic mutations and the manifestation of mitochondrial diseases, which is fundamental to develop effective treatments for these pathologies.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Filipovska, Aleksandra, Supervisor
  • Richman, Tara, Supervisor
Award date15 May 2020
DOIs
Publication statusUnpublished - 2020

Embargo information

  • Embargoed from 25/05/2020 to 25/05/2022. Made publicly available on 25/05/2022.

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