Risk of persistent or recurrent neoplasia in conservatively treated women with cervical adenocarcinoma in situ with negative histological margins

Aime Munro; Jim Codde; Katrina Spilsbury; Colin J R Stewart; Nerida Steel; Yee Leung; Jason Tan; Stuart G. Salfinger; Ganendra R. Mohan; James B. Semmens; Paul A. Cohen

doi:10.1111/aogs.13110

Risk of persistent or recurrent neoplasia in conservatively treated women with cervical adenocarcinoma in situ with negative histological margins

Aime Munro, Jim Codde, Katrina Spilsbury, Colin J R Stewart, Nerida Steel, Yee Leung, Jason Tan, Stuart G. Salfinger, Ganendra R. Mohan, James B. Semmens, Paul A. Cohen

Centre for Respiratory Health

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Introduction: Conservative treatments including cold knife cone biopsy (CKC) or loop electrosurgical excision procedure (LEEP) are fertility-preserving alternatives to hysterectomy. The risks of persistent cervical neoplasia in women with negative surgical margins following conservative treatment of adenocarcinoma-in-situ (AIS) are uncertain. This study aims to investigate the risk of persistent or recurrent cervical neoplasia [AIS, adenocarcinoma and/or high-grade cervical squamous intraepithelial neoplasia (CIN)] and compliance with follow-up recommendations in conservatively treated women with AIS and negative histopathological margins. Material and methods: A retrospective, population-based study of Western Australian women treated by CKC or LEEP for AIS between 2001 and 2012. Histopathology reports were reviewed for demographic information, treatment procedures and clinicopathological factors. Primary outcomes were the diagnosis of cervical neoplasia during follow-up (defined as

Original language	English
Pages (from-to)	432-437
Number of pages	6
Journal	Acta Obstetricia et Gynecologica Scandinavica
Volume	96
Issue number	4
DOIs	https://doi.org/10.1111/aogs.13110
Publication status	Published - 1 Apr 2017

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Munro, A., Codde, J., Spilsbury, K., Stewart, C. J. R., Steel, N., Leung, Y., Tan, J., Salfinger, S. G., Mohan, G. R., Semmens, J. B., & Cohen, P. A. (2017). Risk of persistent or recurrent neoplasia in conservatively treated women with cervical adenocarcinoma in situ with negative histological margins. Acta Obstetricia et Gynecologica Scandinavica, 96(4), 432-437. https://doi.org/10.1111/aogs.13110

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title = "Risk of persistent or recurrent neoplasia in conservatively treated women with cervical adenocarcinoma in situ with negative histological margins",

abstract = "Introduction: Conservative treatments including cold knife cone biopsy (CKC) or loop electrosurgical excision procedure (LEEP) are fertility-preserving alternatives to hysterectomy. The risks of persistent cervical neoplasia in women with negative surgical margins following conservative treatment of adenocarcinoma-in-situ (AIS) are uncertain. This study aims to investigate the risk of persistent or recurrent cervical neoplasia [AIS, adenocarcinoma and/or high-grade cervical squamous intraepithelial neoplasia (CIN)] and compliance with follow-up recommendations in conservatively treated women with AIS and negative histopathological margins. Material and methods: A retrospective, population-based study of Western Australian women treated by CKC or LEEP for AIS between 2001 and 2012. Histopathology reports were reviewed for demographic information, treatment procedures and clinicopathological factors. Primary outcomes were the diagnosis of cervical neoplasia during follow-up (defined as ",

keywords = "adenocarcinoma-in-situ, Cervical neoplasia, cold knife cone biopsy, loop electrosurgical excision procedure, women",

author = "Aime Munro and Jim Codde and Katrina Spilsbury and Stewart, {Colin J R} and Nerida Steel and Yee Leung and Jason Tan and Salfinger, {Stuart G.} and Mohan, {Ganendra R.} and Semmens, {James B.} and Cohen, {Paul A.}",

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Munro, A, Codde, J, Spilsbury, K, Stewart, CJR, Steel, N, Leung, Y, Tan, J, Salfinger, SG, Mohan, GR, Semmens, JB & Cohen, PA 2017, 'Risk of persistent or recurrent neoplasia in conservatively treated women with cervical adenocarcinoma in situ with negative histological margins', Acta Obstetricia et Gynecologica Scandinavica, vol. 96, no. 4, pp. 432-437. https://doi.org/10.1111/aogs.13110

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AU - Munro, Aime

AU - Codde, Jim

AU - Spilsbury, Katrina

AU - Stewart, Colin J R

AU - Steel, Nerida

AU - Leung, Yee

AU - Tan, Jason

AU - Salfinger, Stuart G.

AU - Mohan, Ganendra R.

AU - Semmens, James B.

AU - Cohen, Paul A.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Introduction: Conservative treatments including cold knife cone biopsy (CKC) or loop electrosurgical excision procedure (LEEP) are fertility-preserving alternatives to hysterectomy. The risks of persistent cervical neoplasia in women with negative surgical margins following conservative treatment of adenocarcinoma-in-situ (AIS) are uncertain. This study aims to investigate the risk of persistent or recurrent cervical neoplasia [AIS, adenocarcinoma and/or high-grade cervical squamous intraepithelial neoplasia (CIN)] and compliance with follow-up recommendations in conservatively treated women with AIS and negative histopathological margins. Material and methods: A retrospective, population-based study of Western Australian women treated by CKC or LEEP for AIS between 2001 and 2012. Histopathology reports were reviewed for demographic information, treatment procedures and clinicopathological factors. Primary outcomes were the diagnosis of cervical neoplasia during follow-up (defined as

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Risk of persistent or recurrent neoplasia in conservatively treated women with cervical adenocarcinoma in situ with negative histological margins

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