Risk of persistent or recurrent neoplasia in conservatively treated women with cervical adenocarcinoma in situ with negative histological margins

Aime Munro, Jim Codde, Katrina Spilsbury, Colin J R Stewart, Nerida Steel, Yee Leung, Jason Tan, Stuart G. Salfinger, Ganendra R. Mohan, James B. Semmens, Paul A. Cohen

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: Conservative treatments including cold knife cone biopsy (CKC) or loop electrosurgical excision procedure (LEEP) are fertility-preserving alternatives to hysterectomy. The risks of persistent cervical neoplasia in women with negative surgical margins following conservative treatment of adenocarcinoma-in-situ (AIS) are uncertain. This study aims to investigate the risk of persistent or recurrent cervical neoplasia [AIS, adenocarcinoma and/or high-grade cervical squamous intraepithelial neoplasia (CIN)] and compliance with follow-up recommendations in conservatively treated women with AIS and negative histopathological margins. Material and methods: A retrospective, population-based study of Western Australian women treated by CKC or LEEP for AIS between 2001 and 2012. Histopathology reports were reviewed for demographic information, treatment procedures and clinicopathological factors. Primary outcomes were the diagnosis of cervical neoplasia during follow-up (defined as

Original languageEnglish
Pages (from-to)432-437
Number of pages6
JournalActa Obstetricia et Gynecologica Scandinavica
Volume96
Issue number4
DOIs
Publication statusPublished - 1 Apr 2017

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Neoplasms
Biopsy
Cervical Intraepithelial Neoplasia
Hysterectomy
Fertility
Adenocarcinoma
Demography
Adenocarcinoma in Situ
Population
Conservative Treatment
Therapeutics
Margins of Excision

Cite this

Munro, Aime ; Codde, Jim ; Spilsbury, Katrina ; Stewart, Colin J R ; Steel, Nerida ; Leung, Yee ; Tan, Jason ; Salfinger, Stuart G. ; Mohan, Ganendra R. ; Semmens, James B. ; Cohen, Paul A. / Risk of persistent or recurrent neoplasia in conservatively treated women with cervical adenocarcinoma in situ with negative histological margins. In: Acta Obstetricia et Gynecologica Scandinavica. 2017 ; Vol. 96, No. 4. pp. 432-437.
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Risk of persistent or recurrent neoplasia in conservatively treated women with cervical adenocarcinoma in situ with negative histological margins. / Munro, Aime; Codde, Jim; Spilsbury, Katrina; Stewart, Colin J R; Steel, Nerida; Leung, Yee; Tan, Jason; Salfinger, Stuart G.; Mohan, Ganendra R.; Semmens, James B.; Cohen, Paul A.

In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 96, No. 4, 01.04.2017, p. 432-437.

Research output: Contribution to journalArticle

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AU - Steel, Nerida

AU - Leung, Yee

AU - Tan, Jason

AU - Salfinger, Stuart G.

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AU - Cohen, Paul A.

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