Risk of Central Nervous System Tumors in Children Related to Parental Occupational Pesticide Exposures in three European Case-Control Studies

Olivia Febvey, Joachim Schüz, Helen D Bailey, Jacqueline Clavel, Brigitte Lacour, Laurent Orsi, Tracy Lightfoot, Eve Roman, Roel Vermeulen, Hans Kromhout, Ann Olsson

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

OBJECTIVE: The aim of this study was to assess the risk of childhood central nervous system (CNS) tumors associated with parental occupational pesticide exposure.

METHODS: We pooled three population-based case-control studies from France, Germany, and the United Kingdom. Cases were children below 15 years of age with CNS tumors; controls were matched by gender and age. A general population job-exposure matrix assessed parental occupational pesticide exposure. Logistic regressions estimated odds ratios (ORs) and 95% confidence intervals (CIs).

RESULTS: The study included 1361 cases and 5498 controls. Prevalence of maternal occupational pesticide exposure during pregnancy was low and no association with childhood CNS tumors was detected (OR 0.76, 95% CI: 0.41 to 1.41). Around conception, OR for childhood CNS tumors associated with paternal occupational pesticide exposure was 0.71 (95% CI: 0.53 to 0.95).

CONCLUSION: Our results do not suggest a role of parental occupational pesticide exposure in the etiology of childhood CNS tumors.

Original languageEnglish
Pages (from-to)1046-1052
Number of pages7
JournalJournal of Occupational and Environmental Medicine
Volume58
Issue number10
DOIs
Publication statusPublished - Oct 2016
Externally publishedYes

Fingerprint Dive into the research topics of 'Risk of Central Nervous System Tumors in Children Related to Parental Occupational Pesticide Exposures in three European Case-Control Studies'. Together they form a unique fingerprint.

Cite this