Risk of Central Nervous System Tumors in Children Related to Parental Occupational Pesticide Exposures in three European Case-Control Studies

Olivia Febvey, Joachim Schüz, Helen D Bailey, Jacqueline Clavel, Brigitte Lacour, Laurent Orsi, Tracy Lightfoot, Eve Roman, Roel Vermeulen, Hans Kromhout, Ann Olsson

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

OBJECTIVE: The aim of this study was to assess the risk of childhood central nervous system (CNS) tumors associated with parental occupational pesticide exposure.

METHODS: We pooled three population-based case-control studies from France, Germany, and the United Kingdom. Cases were children below 15 years of age with CNS tumors; controls were matched by gender and age. A general population job-exposure matrix assessed parental occupational pesticide exposure. Logistic regressions estimated odds ratios (ORs) and 95% confidence intervals (CIs).

RESULTS: The study included 1361 cases and 5498 controls. Prevalence of maternal occupational pesticide exposure during pregnancy was low and no association with childhood CNS tumors was detected (OR 0.76, 95% CI: 0.41 to 1.41). Around conception, OR for childhood CNS tumors associated with paternal occupational pesticide exposure was 0.71 (95% CI: 0.53 to 0.95).

CONCLUSION: Our results do not suggest a role of parental occupational pesticide exposure in the etiology of childhood CNS tumors.

Original languageEnglish
Pages (from-to)1046-1052
Number of pages7
JournalJournal of Occupational and Environmental Medicine
Volume58
Issue number10
DOIs
Publication statusPublished - Oct 2016
Externally publishedYes

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Central Nervous System Neoplasms
Occupational Exposure
Pesticides
Case-Control Studies
Odds Ratio
Confidence Intervals
Population
France
Germany
Logistic Models
Mothers
Pregnancy

Cite this

Febvey, Olivia ; Schüz, Joachim ; Bailey, Helen D ; Clavel, Jacqueline ; Lacour, Brigitte ; Orsi, Laurent ; Lightfoot, Tracy ; Roman, Eve ; Vermeulen, Roel ; Kromhout, Hans ; Olsson, Ann. / Risk of Central Nervous System Tumors in Children Related to Parental Occupational Pesticide Exposures in three European Case-Control Studies. In: Journal of Occupational and Environmental Medicine. 2016 ; Vol. 58, No. 10. pp. 1046-1052.
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abstract = "OBJECTIVE: The aim of this study was to assess the risk of childhood central nervous system (CNS) tumors associated with parental occupational pesticide exposure.METHODS: We pooled three population-based case-control studies from France, Germany, and the United Kingdom. Cases were children below 15 years of age with CNS tumors; controls were matched by gender and age. A general population job-exposure matrix assessed parental occupational pesticide exposure. Logistic regressions estimated odds ratios (ORs) and 95{\%} confidence intervals (CIs).RESULTS: The study included 1361 cases and 5498 controls. Prevalence of maternal occupational pesticide exposure during pregnancy was low and no association with childhood CNS tumors was detected (OR 0.76, 95{\%} CI: 0.41 to 1.41). Around conception, OR for childhood CNS tumors associated with paternal occupational pesticide exposure was 0.71 (95{\%} CI: 0.53 to 0.95).CONCLUSION: Our results do not suggest a role of parental occupational pesticide exposure in the etiology of childhood CNS tumors.",
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Risk of Central Nervous System Tumors in Children Related to Parental Occupational Pesticide Exposures in three European Case-Control Studies. / Febvey, Olivia; Schüz, Joachim; Bailey, Helen D; Clavel, Jacqueline; Lacour, Brigitte; Orsi, Laurent; Lightfoot, Tracy; Roman, Eve; Vermeulen, Roel; Kromhout, Hans; Olsson, Ann.

In: Journal of Occupational and Environmental Medicine, Vol. 58, No. 10, 10.2016, p. 1046-1052.

Research output: Contribution to journalArticle

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T1 - Risk of Central Nervous System Tumors in Children Related to Parental Occupational Pesticide Exposures in three European Case-Control Studies

AU - Febvey, Olivia

AU - Schüz, Joachim

AU - Bailey, Helen D

AU - Clavel, Jacqueline

AU - Lacour, Brigitte

AU - Orsi, Laurent

AU - Lightfoot, Tracy

AU - Roman, Eve

AU - Vermeulen, Roel

AU - Kromhout, Hans

AU - Olsson, Ann

PY - 2016/10

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N2 - OBJECTIVE: The aim of this study was to assess the risk of childhood central nervous system (CNS) tumors associated with parental occupational pesticide exposure.METHODS: We pooled three population-based case-control studies from France, Germany, and the United Kingdom. Cases were children below 15 years of age with CNS tumors; controls were matched by gender and age. A general population job-exposure matrix assessed parental occupational pesticide exposure. Logistic regressions estimated odds ratios (ORs) and 95% confidence intervals (CIs).RESULTS: The study included 1361 cases and 5498 controls. Prevalence of maternal occupational pesticide exposure during pregnancy was low and no association with childhood CNS tumors was detected (OR 0.76, 95% CI: 0.41 to 1.41). Around conception, OR for childhood CNS tumors associated with paternal occupational pesticide exposure was 0.71 (95% CI: 0.53 to 0.95).CONCLUSION: Our results do not suggest a role of parental occupational pesticide exposure in the etiology of childhood CNS tumors.

AB - OBJECTIVE: The aim of this study was to assess the risk of childhood central nervous system (CNS) tumors associated with parental occupational pesticide exposure.METHODS: We pooled three population-based case-control studies from France, Germany, and the United Kingdom. Cases were children below 15 years of age with CNS tumors; controls were matched by gender and age. A general population job-exposure matrix assessed parental occupational pesticide exposure. Logistic regressions estimated odds ratios (ORs) and 95% confidence intervals (CIs).RESULTS: The study included 1361 cases and 5498 controls. Prevalence of maternal occupational pesticide exposure during pregnancy was low and no association with childhood CNS tumors was detected (OR 0.76, 95% CI: 0.41 to 1.41). Around conception, OR for childhood CNS tumors associated with paternal occupational pesticide exposure was 0.71 (95% CI: 0.53 to 0.95).CONCLUSION: Our results do not suggest a role of parental occupational pesticide exposure in the etiology of childhood CNS tumors.

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