Risk factors associated with Helicobacter pylori infection in the urban population of China: A nationwide, multi-center, cross-sectional study

Liang Wang; Zheng-Kang Li; Jin-Xin Lai; Yu-Ting Si; Jie Chen; Eng Guan Chua; Ling-Yan Dai; Qiong Dai; Xu-Bo Dai; Zhao-Hui Deng; Hong Du; Qi Fang; Cui Feng; Min He; Guo-Chu Hu; Yi-Zhong Hu; Hui Huang; Yan-Jiang Huang; Fen Li; Jun-Hong Li; Qi-Xin Li; Zhi-Fang Lin; Hai-Tao Liu; Ming-Bo Liu; Jin-Hua Luo; Jian-Hong Ma; Bao-Hua Man; Xiao-Jun Ru; Bo-Fu Tang; Jia-Wei Tang; Shi-Fu Tang; Yan Tian; Zeeshan Umar; Han-Dong Wang; Ji-Liang Wang; Shu-Chun Wang; Xiao-Ling Wang; Tao Wu; Dong Xia; Qing-Quan Xie; Rong-Zhang Xie; Jian-Cheng Xu; Jing Xu; Yun-Xian Ye; Gai-Ling Yuan; Quan Yuan; Li-Yan Zhang; Xin-Yu Zhang; Shu-Lei Zhao; Bin Zhou; Xing-Cheng Zhu; Wen-Bi Zou; Barry J Marshall; Alfred Chin Yen Tay; Zhi-Bo Hou; Bing Gu

doi:10.1016/j.ijid.2025.107890

Risk factors associated with Helicobacter pylori infection in the urban population of China: A nationwide, multi-center, cross-sectional study

Liang Wang, Zheng-Kang Li, Jin-Xin Lai, Yu-Ting Si, Jie Chen, Eng Guan Chua, Ling-Yan Dai, Qiong Dai, Xu-Bo Dai, Zhao-Hui Deng, Hong Du, Qi Fang, Cui Feng, Min He, Guo-Chu Hu, Yi-Zhong Hu, Hui Huang, Yan-Jiang Huang, Fen Li, Jun-Hong LiQi-Xin Li, Zhi-Fang Lin, Hai-Tao Liu, Ming-Bo Liu, Jin-Hua Luo, Jian-Hong Ma, Bao-Hua Man, Xiao-Jun Ru, Bo-Fu Tang, Jia-Wei Tang, Shi-Fu Tang, Yan Tian, Zeeshan Umar, Han-Dong Wang, Ji-Liang Wang, Shu-Chun Wang, Xiao-Ling Wang, Tao Wu, Dong Xia, Qing-Quan Xie, Rong-Zhang Xie, Jian-Cheng Xu, Jing Xu, Yun-Xian Ye, Gai-Ling Yuan, Quan Yuan, Li-Yan Zhang, Xin-Yu Zhang, Shu-Lei Zhao, Bin Zhou, Xing-Cheng Zhu, Wen-Bi Zou, Barry J Marshall, Alfred Chin Yen Tay, Zhi-Bo Hou, Bing Gu

Research output: Contribution to journal › Article › peer-review

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Abstract

OBJECTIVES: To assess the risk factors associated with Helicobacter pylori infection in the urban Chinese population.

METHODS: The study was conducted from March to November 2023, including 12,902 urban participants aged 18-60 years across 52 cities distributed over 26 provinces in China. Risk factors included socioeconomic status, lifestyles, and public understanding. Univariate and multivariate logistic regression analysis was used to calculate corrected odds ratios (ORs) and 95% confidence intervals (CIs).

RESULTS: According to multivariate logistic regression, risk factors associated with significantly higher H. pylori infection rates included residency in developing (OR 1.27, 95% CI 1.13-1.43) and undeveloped cities (OR 1.15, 95% CI 1.02-1.29), obesity (OR 1.37, 95% CI 1.05-1.78), alcohol consumption (OR 1.16, 95% CI 1.05-1.29), tea consumption (OR 1.11, 95% CI 1.01-1.21), and soft drink consumption (OR 1.24, 95% CI 1.09-1.40). Conversely, individuals with moderate awareness (OR 0.79, 95% CI 0.71-0.88) and high awareness (OR 0.57, 95% CI 0.48-0.69) of H. pylori had lower infection rates.

CONCLUSION: Our findings highlight the importance of promoting a healthy lifestyle and improving the understanding of H. pylori in reducing the infection rate of the bacterial pathogen in the urban Chinese population.

Original language	English
Article number	107890
Number of pages	8
Journal	International Journal of Infectious Diseases
Volume	154
Early online date	30 Mar 2025
DOIs	https://doi.org/10.1016/j.ijid.2025.107890
Publication status	Published - May 2025

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Wang, L., Li, Z.-K., Lai, J.-X., Si, Y.-T., Chen, J., Chua, E. G., Dai, L.-Y., Dai, Q., Dai, X.-B., Deng, Z.-H., Du, H., Fang, Q., Feng, C., He, M., Hu, G.-C., Hu, Y.-Z., Huang, H., Huang, Y.-J., Li, F., ... Gu, B. (2025). Risk factors associated with Helicobacter pylori infection in the urban population of China: A nationwide, multi-center, cross-sectional study. International Journal of Infectious Diseases, 154, Article 107890. https://doi.org/10.1016/j.ijid.2025.107890

@article{f65b9fc43aef4fc4829324a3b470ffb5,

title = "Risk factors associated with Helicobacter pylori infection in the urban population of China: A nationwide, multi-center, cross-sectional study",

abstract = "OBJECTIVES: To assess the risk factors associated with Helicobacter pylori infection in the urban Chinese population.METHODS: The study was conducted from March to November 2023, including 12,902 urban participants aged 18-60 years across 52 cities distributed over 26 provinces in China. Risk factors included socioeconomic status, lifestyles, and public understanding. Univariate and multivariate logistic regression analysis was used to calculate corrected odds ratios (ORs) and 95% confidence intervals (CIs).RESULTS: According to multivariate logistic regression, risk factors associated with significantly higher H. pylori infection rates included residency in developing (OR 1.27, 95% CI 1.13-1.43) and undeveloped cities (OR 1.15, 95% CI 1.02-1.29), obesity (OR 1.37, 95% CI 1.05-1.78), alcohol consumption (OR 1.16, 95% CI 1.05-1.29), tea consumption (OR 1.11, 95% CI 1.01-1.21), and soft drink consumption (OR 1.24, 95% CI 1.09-1.40). Conversely, individuals with moderate awareness (OR 0.79, 95% CI 0.71-0.88) and high awareness (OR 0.57, 95% CI 0.48-0.69) of H. pylori had lower infection rates.CONCLUSION: Our findings highlight the importance of promoting a healthy lifestyle and improving the understanding of H. pylori in reducing the infection rate of the bacterial pathogen in the urban Chinese population.",

author = "Liang Wang and Zheng-Kang Li and Jin-Xin Lai and Yu-Ting Si and Jie Chen and Chua, {Eng Guan} and Ling-Yan Dai and Qiong Dai and Xu-Bo Dai and Zhao-Hui Deng and Hong Du and Qi Fang and Cui Feng and Min He and Guo-Chu Hu and Yi-Zhong Hu and Hui Huang and Yan-Jiang Huang and Fen Li and Jun-Hong Li and Qi-Xin Li and Zhi-Fang Lin and Hai-Tao Liu and Ming-Bo Liu and Jin-Hua Luo and Jian-Hong Ma and Bao-Hua Man and Xiao-Jun Ru and Bo-Fu Tang and Jia-Wei Tang and Shi-Fu Tang and Yan Tian and Zeeshan Umar and Han-Dong Wang and Ji-Liang Wang and Shu-Chun Wang and Xiao-Ling Wang and Tao Wu and Dong Xia and Qing-Quan Xie and Rong-Zhang Xie and Jian-Cheng Xu and Jing Xu and Yun-Xian Ye and Gai-Ling Yuan and Quan Yuan and Li-Yan Zhang and Xin-Yu Zhang and Shu-Lei Zhao and Bin Zhou and Xing-Cheng Zhu and Wen-Bi Zou and Marshall, {Barry J} and Tay, {Alfred Chin Yen} and Zhi-Bo Hou and Bing Gu",

year = "2025",

month = may,

doi = "10.1016/j.ijid.2025.107890",

language = "English",

volume = "154",

journal = "International Journal of Infectious Diseases",

issn = "1201-9712",

publisher = "Elsevier",

}

Wang, L, Li, Z-K, Lai, J-X, Si, Y-T, Chen, J, Chua, EG, Dai, L-Y, Dai, Q, Dai, X-B, Deng, Z-H, Du, H, Fang, Q, Feng, C, He, M, Hu, G-C, Hu, Y-Z, Huang, H, Huang, Y-J, Li, F, Li, J-H, Li, Q-X, Lin, Z-F, Liu, H-T, Liu, M-B, Luo, J-H, Ma, J-H, Man, B-H, Ru, X-J, Tang, B-F, Tang, J-W, Tang, S-F, Tian, Y, Umar, Z, Wang, H-D, Wang, J-L, Wang, S-C, Wang, X-L, Wu, T, Xia, D, Xie, Q-Q, Xie, R-Z, Xu, J-C, Xu, J, Ye, Y-X, Yuan, G-L, Yuan, Q, Zhang, L-Y, Zhang, X-Y, Zhao, S-L, Zhou, B, Zhu, X-C, Zou, W-B, Marshall, BJ , Tay, ACY, Hou, Z-B & Gu, B 2025, 'Risk factors associated with Helicobacter pylori infection in the urban population of China: A nationwide, multi-center, cross-sectional study', International Journal of Infectious Diseases, vol. 154, 107890. https://doi.org/10.1016/j.ijid.2025.107890

TY - JOUR

T1 - Risk factors associated with Helicobacter pylori infection in the urban population of China

T2 - A nationwide, multi-center, cross-sectional study

AU - Wang, Liang

AU - Li, Zheng-Kang

AU - Lai, Jin-Xin

AU - Si, Yu-Ting

AU - Chen, Jie

AU - Chua, Eng Guan

AU - Dai, Ling-Yan

AU - Dai, Qiong

AU - Dai, Xu-Bo

AU - Deng, Zhao-Hui

AU - Du, Hong

AU - Fang, Qi

AU - Feng, Cui

AU - He, Min

AU - Hu, Guo-Chu

AU - Hu, Yi-Zhong

AU - Huang, Hui

AU - Huang, Yan-Jiang

AU - Li, Fen

AU - Li, Jun-Hong

AU - Li, Qi-Xin

AU - Lin, Zhi-Fang

AU - Liu, Hai-Tao

AU - Liu, Ming-Bo

AU - Luo, Jin-Hua

AU - Ma, Jian-Hong

AU - Man, Bao-Hua

AU - Ru, Xiao-Jun

AU - Tang, Bo-Fu

AU - Tang, Jia-Wei

AU - Tang, Shi-Fu

AU - Tian, Yan

AU - Umar, Zeeshan

AU - Wang, Han-Dong

AU - Wang, Ji-Liang

AU - Wang, Shu-Chun

AU - Wang, Xiao-Ling

AU - Wu, Tao

AU - Xia, Dong

AU - Xie, Qing-Quan

AU - Xie, Rong-Zhang

AU - Xu, Jian-Cheng

AU - Xu, Jing

AU - Ye, Yun-Xian

AU - Yuan, Gai-Ling

AU - Yuan, Quan

AU - Zhang, Li-Yan

AU - Zhang, Xin-Yu

AU - Zhao, Shu-Lei

AU - Zhou, Bin

AU - Zhu, Xing-Cheng

AU - Zou, Wen-Bi

AU - Marshall, Barry J

AU - Tay, Alfred Chin Yen

AU - Hou, Zhi-Bo

AU - Gu, Bing

PY - 2025/5

Y1 - 2025/5

N2 - OBJECTIVES: To assess the risk factors associated with Helicobacter pylori infection in the urban Chinese population.METHODS: The study was conducted from March to November 2023, including 12,902 urban participants aged 18-60 years across 52 cities distributed over 26 provinces in China. Risk factors included socioeconomic status, lifestyles, and public understanding. Univariate and multivariate logistic regression analysis was used to calculate corrected odds ratios (ORs) and 95% confidence intervals (CIs).RESULTS: According to multivariate logistic regression, risk factors associated with significantly higher H. pylori infection rates included residency in developing (OR 1.27, 95% CI 1.13-1.43) and undeveloped cities (OR 1.15, 95% CI 1.02-1.29), obesity (OR 1.37, 95% CI 1.05-1.78), alcohol consumption (OR 1.16, 95% CI 1.05-1.29), tea consumption (OR 1.11, 95% CI 1.01-1.21), and soft drink consumption (OR 1.24, 95% CI 1.09-1.40). Conversely, individuals with moderate awareness (OR 0.79, 95% CI 0.71-0.88) and high awareness (OR 0.57, 95% CI 0.48-0.69) of H. pylori had lower infection rates.CONCLUSION: Our findings highlight the importance of promoting a healthy lifestyle and improving the understanding of H. pylori in reducing the infection rate of the bacterial pathogen in the urban Chinese population.

AB - OBJECTIVES: To assess the risk factors associated with Helicobacter pylori infection in the urban Chinese population.METHODS: The study was conducted from March to November 2023, including 12,902 urban participants aged 18-60 years across 52 cities distributed over 26 provinces in China. Risk factors included socioeconomic status, lifestyles, and public understanding. Univariate and multivariate logistic regression analysis was used to calculate corrected odds ratios (ORs) and 95% confidence intervals (CIs).RESULTS: According to multivariate logistic regression, risk factors associated with significantly higher H. pylori infection rates included residency in developing (OR 1.27, 95% CI 1.13-1.43) and undeveloped cities (OR 1.15, 95% CI 1.02-1.29), obesity (OR 1.37, 95% CI 1.05-1.78), alcohol consumption (OR 1.16, 95% CI 1.05-1.29), tea consumption (OR 1.11, 95% CI 1.01-1.21), and soft drink consumption (OR 1.24, 95% CI 1.09-1.40). Conversely, individuals with moderate awareness (OR 0.79, 95% CI 0.71-0.88) and high awareness (OR 0.57, 95% CI 0.48-0.69) of H. pylori had lower infection rates.CONCLUSION: Our findings highlight the importance of promoting a healthy lifestyle and improving the understanding of H. pylori in reducing the infection rate of the bacterial pathogen in the urban Chinese population.

U2 - 10.1016/j.ijid.2025.107890

DO - 10.1016/j.ijid.2025.107890

M3 - Article

C2 - 40096882

SN - 1201-9712

VL - 154

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

M1 - 107890

ER -

Risk factors associated with Helicobacter pylori infection in the urban population of China: A nationwide, multi-center, cross-sectional study

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