REVERSAL OF NAFLD AND THE GLOBAL OBESITY EPIDEMIC

Novel research indicates that the global non alcoholic fatty liver disease (NAFLD) epidemic is critical to the induction of the obesity epidemic. In man dietary and drug interventions in obesity have failed to correct the defect in the adipose tissue-liver interaction with the induction of NAFLD and NAFLD to effect between 20-40% of the global population. In various studies in obese animals dietary restriction has improved the adipose tissue-liver interaction with increased hepatic metabolism of lipids. Mitochondrial apoptosis is now a major concern in NAFLD with defective lipid metabolism in adipocytes related to adiposity and NAFLD. Specific genes have been identified that regulate the adipose tissue-liver interaction with calorie sensitive genes essential to maintain the interaction with the prevention of obesity. Global populations include various racial groups with consumption of anti-aging gene nutrients that may vary considerably between Caucasians, Africans, Europeans, Hispanics, Pacific Islanders and Asians. Nutritional and environmental epigenetics now identify the calorie sensitive gene Sirtuin 1 (Sirt 1) to be critical to the reversal of NAFLD and obesity. Sirt 1 is important to mitochondrial biogenesis with Sirt 1 repression responsible for the adipose tissue-liver defect. Nutritional diets that contain Sirt 1 activators reverse NAFLD with relevance to obesity and various global chronic diseases.