Retrospective investigation of postoperative outcome after reversal of residual neuromuscular blockade: Sugammadex, neostigmine or no reversal

Thomas Ledowski; L. Falke; F. Johnston; Emily Gillies; Matthew Greenaway; Ayala De Mel; Eda Tiong; Michael Phillips

doi:10.1097/EJA.0000000000000010

Retrospective investigation of postoperative outcome after reversal of residual neuromuscular blockade: Sugammadex, neostigmine or no reversal

Thomas Ledowski, L. Falke, F. Johnston, Emily Gillies, Matthew Greenaway, Ayala De Mel, Eda Tiong, Michael Phillips

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Abstract

BACKGROUND Postoperative residual neuromuscular blockade (RNMB) is associated with significant morbidity. OBJECTIVE The aim of this retrospective data analysis was to investigate the influence of the method of RNMB reversal on postoperative outcome. SETTING Tertiary teaching hospital in Western Australia. PATIENTS With Ethics Committee approval, data from 1444 patients who received at least one dose of a non-depolarising muscle relaxant intraoperatively during 2011 were analysed. MAIN OUTCOME MEASURES Endpoints included unwanted events in the postanaesthesia care unit (PACU); symptoms of pulmonary complications within 7 postoperative days (0 to 100 outcome score based on 'temperature >388C', 'leucocyte count >11109 l±1', 'physical examination consistent with pneumonia' and 'shortness of breath'); PACU turnover time; and length of hospital stay. RESULTS Data from 1444 patients (722 sugammadex, 212 neostigmine and 510 no-reversal) were analysed. The incidence of postoperative nausea and vomiting (PONV) in PACU was higher in neostigmine-reversed than sugammadex-reversed patients (21.5 vs. 13.6%; P

Original language	English
Pages (from-to)	423-429
Journal	European Journal of Anaesthesiology
Volume	31
Issue number	8
DOIs	https://doi.org/10.1097/EJA.0000000000000010
Publication status	Published - 2014

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title = "Retrospective investigation of postoperative outcome after reversal of residual neuromuscular blockade: Sugammadex, neostigmine or no reversal",

abstract = "BACKGROUND Postoperative residual neuromuscular blockade (RNMB) is associated with significant morbidity. OBJECTIVE The aim of this retrospective data analysis was to investigate the influence of the method of RNMB reversal on postoperative outcome. SETTING Tertiary teaching hospital in Western Australia. PATIENTS With Ethics Committee approval, data from 1444 patients who received at least one dose of a non-depolarising muscle relaxant intraoperatively during 2011 were analysed. MAIN OUTCOME MEASURES Endpoints included unwanted events in the postanaesthesia care unit (PACU); symptoms of pulmonary complications within 7 postoperative days (0 to 100 outcome score based on 'temperature >388C', 'leucocyte count >11109 l±1', 'physical examination consistent with pneumonia' and 'shortness of breath'); PACU turnover time; and length of hospital stay. RESULTS Data from 1444 patients (722 sugammadex, 212 neostigmine and 510 no-reversal) were analysed. The incidence of postoperative nausea and vomiting (PONV) in PACU was higher in neostigmine-reversed than sugammadex-reversed patients (21.5 vs. 13.6%; P",

author = "Thomas Ledowski and L. Falke and F. Johnston and Emily Gillies and Matthew Greenaway and {De Mel}, Ayala and Eda Tiong and Michael Phillips",

year = "2014",

doi = "10.1097/EJA.0000000000000010",

language = "English",

volume = "31",

pages = "423--429",

journal = "European Journal of Anaesthesiology",

issn = "0265-0215",

publisher = "Lippincott Williams & Wilkins",

number = "8",

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TY - JOUR

T1 - Retrospective investigation of postoperative outcome after reversal of residual neuromuscular blockade: Sugammadex, neostigmine or no reversal

AU - Ledowski, Thomas

AU - Falke, L.

AU - Johnston, F.

AU - Gillies, Emily

AU - Greenaway, Matthew

AU - De Mel, Ayala

AU - Tiong, Eda

AU - Phillips, Michael

PY - 2014

Y1 - 2014

N2 - BACKGROUND Postoperative residual neuromuscular blockade (RNMB) is associated with significant morbidity. OBJECTIVE The aim of this retrospective data analysis was to investigate the influence of the method of RNMB reversal on postoperative outcome. SETTING Tertiary teaching hospital in Western Australia. PATIENTS With Ethics Committee approval, data from 1444 patients who received at least one dose of a non-depolarising muscle relaxant intraoperatively during 2011 were analysed. MAIN OUTCOME MEASURES Endpoints included unwanted events in the postanaesthesia care unit (PACU); symptoms of pulmonary complications within 7 postoperative days (0 to 100 outcome score based on 'temperature >388C', 'leucocyte count >11109 l±1', 'physical examination consistent with pneumonia' and 'shortness of breath'); PACU turnover time; and length of hospital stay. RESULTS Data from 1444 patients (722 sugammadex, 212 neostigmine and 510 no-reversal) were analysed. The incidence of postoperative nausea and vomiting (PONV) in PACU was higher in neostigmine-reversed than sugammadex-reversed patients (21.5 vs. 13.6%; P

AB - BACKGROUND Postoperative residual neuromuscular blockade (RNMB) is associated with significant morbidity. OBJECTIVE The aim of this retrospective data analysis was to investigate the influence of the method of RNMB reversal on postoperative outcome. SETTING Tertiary teaching hospital in Western Australia. PATIENTS With Ethics Committee approval, data from 1444 patients who received at least one dose of a non-depolarising muscle relaxant intraoperatively during 2011 were analysed. MAIN OUTCOME MEASURES Endpoints included unwanted events in the postanaesthesia care unit (PACU); symptoms of pulmonary complications within 7 postoperative days (0 to 100 outcome score based on 'temperature >388C', 'leucocyte count >11109 l±1', 'physical examination consistent with pneumonia' and 'shortness of breath'); PACU turnover time; and length of hospital stay. RESULTS Data from 1444 patients (722 sugammadex, 212 neostigmine and 510 no-reversal) were analysed. The incidence of postoperative nausea and vomiting (PONV) in PACU was higher in neostigmine-reversed than sugammadex-reversed patients (21.5 vs. 13.6%; P

U2 - 10.1097/EJA.0000000000000010

DO - 10.1097/EJA.0000000000000010

M3 - Article

C2 - 24296853

SN - 0265-0215

VL - 31

SP - 423

EP - 429

JO - European Journal of Anaesthesiology

JF - European Journal of Anaesthesiology

IS - 8

ER -

Retrospective investigation of postoperative outcome after reversal of residual neuromuscular blockade: Sugammadex, neostigmine or no reversal

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