Retrograde Reactions of Clarke's Nucleus Neurons after Human Spinal Cord Injury

A.B. Schmitt, S. Breuer, L. Polar, K. Pech, Byron Kakulas, S. Love, D. Martin, J. Schoenen, J. Noth, G.A. Brook

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Successful axon regeneration depends on the expression of regeneration-associated genes by axotomized neurons. Here, we demonstrate, for the first time to our knowledge, the expression of regeneration-associated genes by axotomized human CNS neurons. In situ hybridization and immunohistochemistry showed a transient induction of GAP-43 and c-jun in Clarke's nucleus neurons caudal to traumatic human spinal cord injury. These results support experimental data that nonregenerating central nervous system neurons can temporarily upregulate regeneration-associated genes, reflecting a transient regenerative capacity that fails over time.
Original languageEnglish
Pages (from-to)534-539
JournalAnnals of Neurology
Volume54
DOIs
Publication statusPublished - 2003

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