Retrograde Flow and Shear Rate Acutely Impair Endothelial Function in Humans

D.H.J. Thijssen, E.A. Dawson, T.M. Tinken, N.T. Cable, Daniel Green

    Research output: Contribution to journalArticlepeer-review

    238 Citations (Scopus)


    Shear stress is an important stimulus to arterial adaptation in response to exercise and training in humans. We recently observed significant reverse arterial flow and shear during exercise and different antegrade/retrograde patterns of shear and flow in response to different types of exercise. The purpose of this study was to simultaneously examine flow-mediated dilation, a largely NO-mediated vasodilator response, in both brachial arteries of healthy young men before and after 30-minute interventions consisting of bilateral forearm heating, recumbent leg cycling, and bilateral handgrip exercise. During each intervention, a cuff inflated to 60 mm Hg was placed on 1 arm to unilaterally manipulate the shear rate stimulus. In the noncuffed arm, antegrade flow and shear increased similarly in response to each intervention (ANOVA; P
    Original languageEnglish
    Pages (from-to)986-992
    Publication statusPublished - 2009


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