Retinopathy of prematurity and placental histopathology findings: A retrospective cohort study

S.E. Athikarisamy, G.C. Lam, M.N. Cooper, T. Strunk

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Aim: Retinopathy of prematurity (ROP) is a biphasic vaso-proliferative disease that has the potential to cause blindness. In addition to prematurity and hyperoxia, perinatal infection and inflammation have been reported to play a critical role in the pathogenesis of ROP. The aim of this study was to assess the association between placental inflammation and the severity of ROP. Methods: A retrospective study of infants (<30 weeks of gestational age) born at the King Edward Memorial Hospital, a tertiary perinatal center in Western Australia. Results: A total of 878 infants were included in this study (ROP stage 0–2 = 829; 3 or more = 49). The presence of maternal chorioamnionitis appeared to show signs of an association with reduced odds of severe ROP: mild chorioamnionitis OR=0.43 (95% CI: 0.17, 1.05) and severe chorioamnionitis OR=0.68 (95% CI: 0.29, 1.60). A strong association was observed for oxygen supplementation at 36 weeks (OR: 5.16; p < 0.001), exposure to postnatal steroids (OR: 6.65; p < 0.001), and receipt of platelet transfusion (OR: 8.21; p < 0.001). Conclusion: Maternal chorioamnionitis or fetal chorioamnionitis was associated with reduced odds of severe ROP. A strong association was found in infants who needed oxygen supplementation at 36 weeks and those who required steroids or platelets in the postnatal period. 2023 Athikarisamy, Lam, Cooper and Strunk.
Original languageEnglish
Article number1099614
JournalFrontiers in Pediatrics
Publication statusPublished - 2023


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  • Screening for Retinopathy of Prematurity

    Athikarisamy, S., 2023, (Unpublished)

    Research output: ThesisDoctoral Thesis

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