TY - JOUR
T1 - Retinal vascular caliber and macular telangiectasia type 2
AU - Tikellis, G.
AU - Gillies, M.C.
AU - Guymer, R.H.
AU - Mcallister, Ian
AU - Shaw, J.E.
AU - Wong, T.Y.
PY - 2009/2
Y1 - 2009/2
N2 - To examine the relationship of retinal vascular caliber to macular telangiectasia (MT) type 2.DesignCase-control study.ParticipantsPatients with MT aged 18 years and older were identified from Australian sites of the multicenter Macular Telangiectasia Project. Three controls per case were selected from participants of the Australian Diabetes, Obesity and Lifestyle study, matched according to age and diabetes status.MethodsBaseline ophthalmic examinations of cases included assessment of best corrected visual acuity, fluorescein angiography, autofluorescence imaging, optical coherence tomography, and retinal photography. Retinal vascular caliber of cases and controls were measured from optic disc-centered digital retinal images by a computer-assisted method.Main Outcome MeasuresMT, central retinal arteriolar, and venular caliber.ResultsThere were 55 cases and 170 controls. After controlling for diastolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, triglycerides, hypertension, fasting plasma glucose, and glycosylated hemoglobin, each standard deviation (SD) increase in retinal arteriolar caliber was associated with a 2-fold higher odds of MT (odds ratio [OR] 2.18; 95% confidence interval [CI], 1.50–3.18). Similarly, each SD increase in retinal venular caliber was associated with increased odds of having MT (OR 1.87; 95% CI, 1.31–2.67).ConclusionsThis study shows that MT is associated with wider arteriolar and venular caliber, measured outside of the foveal area. Generalized changes in retinal vascular caliber may reflect underlying dysfunction in retinal pericytes or glial cells, and may provide a means to monitor progression of disease.
AB - To examine the relationship of retinal vascular caliber to macular telangiectasia (MT) type 2.DesignCase-control study.ParticipantsPatients with MT aged 18 years and older were identified from Australian sites of the multicenter Macular Telangiectasia Project. Three controls per case were selected from participants of the Australian Diabetes, Obesity and Lifestyle study, matched according to age and diabetes status.MethodsBaseline ophthalmic examinations of cases included assessment of best corrected visual acuity, fluorescein angiography, autofluorescence imaging, optical coherence tomography, and retinal photography. Retinal vascular caliber of cases and controls were measured from optic disc-centered digital retinal images by a computer-assisted method.Main Outcome MeasuresMT, central retinal arteriolar, and venular caliber.ResultsThere were 55 cases and 170 controls. After controlling for diastolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, triglycerides, hypertension, fasting plasma glucose, and glycosylated hemoglobin, each standard deviation (SD) increase in retinal arteriolar caliber was associated with a 2-fold higher odds of MT (odds ratio [OR] 2.18; 95% confidence interval [CI], 1.50–3.18). Similarly, each SD increase in retinal venular caliber was associated with increased odds of having MT (OR 1.87; 95% CI, 1.31–2.67).ConclusionsThis study shows that MT is associated with wider arteriolar and venular caliber, measured outside of the foveal area. Generalized changes in retinal vascular caliber may reflect underlying dysfunction in retinal pericytes or glial cells, and may provide a means to monitor progression of disease.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Arterioles/pathology
KW - Case-Control Studies
KW - Female
KW - Fluorescein Angiography
KW - Humans
KW - Male
KW - Middle Aged
KW - Photography
KW - Retinal Artery/pathology
KW - Retinal Diseases/classification
KW - Retinal Vein/pathology
KW - Risk Factors
KW - Signal Processing, Computer-Assisted
KW - Telangiectasis/classification
KW - Tomography, Optical Coherence
KW - Venules/pathology
KW - Visual Acuity
U2 - 10.1016/j.ophtha.2008.09.009
DO - 10.1016/j.ophtha.2008.09.009
M3 - Article
C2 - 19187824
SN - 0161-6420
VL - 116
SP - 319
EP - 323
JO - Ophthalmology
JF - Ophthalmology
IS - 2
ER -