Retinal Capillary Damage is Already Evident in Patients With Hypertension and Prediabetes and Associated With HbA1c Levels in the Nondiabetic Range

Dennis Kannenkeril; Janis M Nolde; Márcio Galindo Kiuchi; Revathy Carnagarin; Leslie Marisol Lugo-Gavidia; Justine Chan; Anu Joyson; Ancy Jose; Sandi Robinson; Vance B Matthews; Lakshini Y Herat; Omar Azzam; Shaun Frost; Markus P Schlaich

doi:10.2337/dc21-1569

Retinal Capillary Damage is Already Evident in Patients With Hypertension and Prediabetes and Associated With HbA_1c Levels in the Nondiabetic Range

Dennis Kannenkeril, Janis M Nolde, Márcio Galindo Kiuchi, Revathy Carnagarin, Leslie Marisol Lugo-Gavidia, Justine Chan, Anu Joyson, Ancy Jose, Sandi Robinson, Vance B Matthews, Lakshini Y Herat, Omar Azzam, Shaun Frost, Markus P Schlaich

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

OBJECTIVE: We analyzed whether any change in capillary density in the retinal circulation could be detected in patients with hypertension in the prediabetic stage.

RESEARCH DESIGN AND METHODS: In a cross-sectional analysis, we assessed capillary density in the foveal (CDF) and parafoveal retinal areas using optical coherence tomography-angiography in 62 patients with hypertension and normal glucose metabolism and 40 patients with hypertension and prediabetes.

RESULTS: The CDF was lower in patients with prediabetes than in those with normal glucose metabolism. Moreover, we found a correlation between CDF and HbA1c and glucose levels for the entire cohort. In patients with HbA1c <6.5% (48 mmol/mol), CDF was lower in patients with HOMA for insulin resistance (HOMA-IR) ≥2.5 than in patients with HOMA-IR <2.5.

CONCLUSIONS: Patients with hypertension and prediabetes display retinal capillary changes, and an association with markers of glucose metabolism exists, even within a nondiabetic HbA1c range.

Original language	English
Pages (from-to)	1472–1475
Number of pages	4
Journal	Diabetes Care
Volume	45
Issue number	6
DOIs	https://doi.org/10.2337/dc21-1569
Publication status	Published - 2 Jun 2022

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Kannenkeril, D., Nolde, J. M., Kiuchi, M. G., Carnagarin, R., Lugo-Gavidia, L. M., Chan, J., Joyson, A., Jose, A., Robinson, S., Matthews, V. B., Herat, L. Y., Azzam, O., Frost, S., & Schlaich, M. P. (2022). Retinal Capillary Damage is Already Evident in Patients With Hypertension and Prediabetes and Associated With HbA_1c Levels in the Nondiabetic Range. Diabetes Care, 45(6), 1472–1475. https://doi.org/10.2337/dc21-1569

@article{a6c366aa463841f89b9fccc067e06fc6,

title = "Retinal Capillary Damage is Already Evident in Patients With Hypertension and Prediabetes and Associated With HbA1c Levels in the Nondiabetic Range",

abstract = "OBJECTIVE: We analyzed whether any change in capillary density in the retinal circulation could be detected in patients with hypertension in the prediabetic stage.RESEARCH DESIGN AND METHODS: In a cross-sectional analysis, we assessed capillary density in the foveal (CDF) and parafoveal retinal areas using optical coherence tomography-angiography in 62 patients with hypertension and normal glucose metabolism and 40 patients with hypertension and prediabetes.RESULTS: The CDF was lower in patients with prediabetes than in those with normal glucose metabolism. Moreover, we found a correlation between CDF and HbA1c and glucose levels for the entire cohort. In patients with HbA1c <6.5% (48 mmol/mol), CDF was lower in patients with HOMA for insulin resistance (HOMA-IR) ≥2.5 than in patients with HOMA-IR <2.5.CONCLUSIONS: Patients with hypertension and prediabetes display retinal capillary changes, and an association with markers of glucose metabolism exists, even within a nondiabetic HbA1c range.",

author = "Dennis Kannenkeril and Nolde, {Janis M} and Kiuchi, {M{\'a}rcio Galindo} and Revathy Carnagarin and Lugo-Gavidia, {Leslie Marisol} and Justine Chan and Anu Joyson and Ancy Jose and Sandi Robinson and Matthews, {Vance B} and Herat, {Lakshini Y} and Omar Azzam and Shaun Frost and Schlaich, {Markus P}",

year = "2022",

month = jun,

day = "2",

doi = "10.2337/dc21-1569",

language = "English",

volume = "45",

pages = "1472–1475",

journal = "Diabetes Care",

issn = "0149-5992",

publisher = "American Diabetes Association",

number = "6",

}

Kannenkeril, D, Nolde, JM, Kiuchi, MG, Carnagarin, R, Lugo-Gavidia, LM, Chan, J, Joyson, A, Jose, A , Robinson, S , Matthews, VB , Herat, LY, Azzam, O, Frost, S & Schlaich, MP 2022, 'Retinal Capillary Damage is Already Evident in Patients With Hypertension and Prediabetes and Associated With HbA_1c Levels in the Nondiabetic Range', Diabetes Care, vol. 45, no. 6, pp. 1472–1475. https://doi.org/10.2337/dc21-1569

TY - JOUR

T1 - Retinal Capillary Damage is Already Evident in Patients With Hypertension and Prediabetes and Associated With HbA1c Levels in the Nondiabetic Range

AU - Kannenkeril, Dennis

AU - Nolde, Janis M

AU - Kiuchi, Márcio Galindo

AU - Carnagarin, Revathy

AU - Lugo-Gavidia, Leslie Marisol

AU - Chan, Justine

AU - Joyson, Anu

AU - Jose, Ancy

AU - Robinson, Sandi

AU - Matthews, Vance B

AU - Herat, Lakshini Y

AU - Azzam, Omar

AU - Frost, Shaun

AU - Schlaich, Markus P

PY - 2022/6/2

Y1 - 2022/6/2

N2 - OBJECTIVE: We analyzed whether any change in capillary density in the retinal circulation could be detected in patients with hypertension in the prediabetic stage.RESEARCH DESIGN AND METHODS: In a cross-sectional analysis, we assessed capillary density in the foveal (CDF) and parafoveal retinal areas using optical coherence tomography-angiography in 62 patients with hypertension and normal glucose metabolism and 40 patients with hypertension and prediabetes.RESULTS: The CDF was lower in patients with prediabetes than in those with normal glucose metabolism. Moreover, we found a correlation between CDF and HbA1c and glucose levels for the entire cohort. In patients with HbA1c <6.5% (48 mmol/mol), CDF was lower in patients with HOMA for insulin resistance (HOMA-IR) ≥2.5 than in patients with HOMA-IR <2.5.CONCLUSIONS: Patients with hypertension and prediabetes display retinal capillary changes, and an association with markers of glucose metabolism exists, even within a nondiabetic HbA1c range.

AB - OBJECTIVE: We analyzed whether any change in capillary density in the retinal circulation could be detected in patients with hypertension in the prediabetic stage.RESEARCH DESIGN AND METHODS: In a cross-sectional analysis, we assessed capillary density in the foveal (CDF) and parafoveal retinal areas using optical coherence tomography-angiography in 62 patients with hypertension and normal glucose metabolism and 40 patients with hypertension and prediabetes.RESULTS: The CDF was lower in patients with prediabetes than in those with normal glucose metabolism. Moreover, we found a correlation between CDF and HbA1c and glucose levels for the entire cohort. In patients with HbA1c <6.5% (48 mmol/mol), CDF was lower in patients with HOMA for insulin resistance (HOMA-IR) ≥2.5 than in patients with HOMA-IR <2.5.CONCLUSIONS: Patients with hypertension and prediabetes display retinal capillary changes, and an association with markers of glucose metabolism exists, even within a nondiabetic HbA1c range.

U2 - 10.2337/dc21-1569

DO - 10.2337/dc21-1569

M3 - Article

C2 - 35344581

SN - 0149-5992

VL - 45

SP - 1472

EP - 1475

JO - Diabetes Care

JF - Diabetes Care

IS - 6

ER -

Retinal Capillary Damage is Already Evident in Patients With Hypertension and Prediabetes and Associated With HbA1c Levels in the Nondiabetic Range

Abstract

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Retinal Capillary Damage is Already Evident in Patients With Hypertension and Prediabetes and Associated With HbA_1c Levels in the Nondiabetic Range