Restoration of defective cross-presentation in tumors by gemcitabine

Alison Mcdonnell; Willem Lesterhuis; Andrea Khong; Anna Nowak; Richard Lake; Andrew Currie; Bruce Robinson

doi:10.1080/2162402X.2015.1005501

Restoration of defective cross-presentation in tumors by gemcitabine

Alison Mcdonnell, Willem Lesterhuis, Andrea Khong, Anna Nowak, Richard Lake, Andrew Currie, Bruce Robinson

Graduate Research School

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

© 2015 Taylor & Francis Group, LLC. Tumor antigen cross-presentation by dendritic cells (DCs) to specific CD8+ T cells is central to antitumor immunity. Although highly efficient in draining lymph nodes, it is defective within the tumor site itself. Importantly, an immunogenic chemotherapy, gemcitabine, reverses this defect, allowing the potential re-stimulation of cytotoxic T lymphocytes within tumor sites.

Original language	English
Pages (from-to)	e1005501
Journal	OncoImmunology
Volume	4
Issue number	5
DOIs	https://doi.org/10.1080/2162402X.2015.1005501
Publication status	Published - 2015

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10.1080/2162402X.2015.1005501

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title = "Restoration of defective cross-presentation in tumors by gemcitabine",

abstract = "{\textcopyright} 2015 Taylor & Francis Group, LLC. Tumor antigen cross-presentation by dendritic cells (DCs) to specific CD8+ T cells is central to antitumor immunity. Although highly efficient in draining lymph nodes, it is defective within the tumor site itself. Importantly, an immunogenic chemotherapy, gemcitabine, reverses this defect, allowing the potential re-stimulation of cytotoxic T lymphocytes within tumor sites.",

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AU - Mcdonnell, Alison

AU - Lesterhuis, Willem

AU - Khong, Andrea

AU - Nowak, Anna

AU - Lake, Richard

AU - Currie, Andrew

AU - Robinson, Bruce

PY - 2015

Y1 - 2015

N2 - © 2015 Taylor & Francis Group, LLC. Tumor antigen cross-presentation by dendritic cells (DCs) to specific CD8+ T cells is central to antitumor immunity. Although highly efficient in draining lymph nodes, it is defective within the tumor site itself. Importantly, an immunogenic chemotherapy, gemcitabine, reverses this defect, allowing the potential re-stimulation of cytotoxic T lymphocytes within tumor sites.

AB - © 2015 Taylor & Francis Group, LLC. Tumor antigen cross-presentation by dendritic cells (DCs) to specific CD8+ T cells is central to antitumor immunity. Although highly efficient in draining lymph nodes, it is defective within the tumor site itself. Importantly, an immunogenic chemotherapy, gemcitabine, reverses this defect, allowing the potential re-stimulation of cytotoxic T lymphocytes within tumor sites.

U2 - 10.1080/2162402X.2015.1005501

DO - 10.1080/2162402X.2015.1005501

M3 - Article

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VL - 4

SP - e1005501

JO - Oncolmmunology

JF - Oncolmmunology

SN - 2162-4011

IS - 5

ER -

Restoration of defective cross-presentation in tumors by gemcitabine

Abstract

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