Resting-state fMRI study of brain activation using low-intensity repetitive transcranial magnetic stimulation in rats

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Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique used to treat many neuropsychiatric conditions. However, the mechanisms underlying its mode of action are still unclear. This is the first rodent study using resting-state functional MRI (rs-fMRI) to examine low-intensity (LI) rTMS effects, in an effort to provide a direct means of comparison between rodent and human studies. Using anaesthetised Sprague-Dawley rats, rs-fMRI data were acquired before and after control or LI-rTMS at 1 Hz, 10 Hz, continuous theta burst stimulation (cTBS) or biomimetic highfrequency stimulation (BHFS). Independent component analysis revealed LI-rTMS-induced changes in the resting-state networks (RSN): (i) in the somatosensory cortex, the synchrony of resting activity decreased ipsilaterally following 10 Hz and bilaterally following 1 Hz stimulation and BHFS, and increased ipsilaterally following cTBS; (ii) the motor cortex showed bilateral changes following 1 Hz and 10 Hz stimulation, a contralateral decrease in synchrony following BHFS, and an ipsilateral increase following cTBS; and (iii) hippocampal synchrony decreased ipsilaterally following 10 Hz, and bilaterally following 1 Hz stimulation and BHFS. The present findings demonstrate that LI-rTMS modulates functional links within the rat RSN with frequency-specific outcomes, and the observed changes are similar to those described in humans following rTMS.

Original languageEnglish
Article number6706
Number of pages13
JournalScientific Reports
Volume8
DOIs
Publication statusPublished - 30 Apr 2018

Activities

  • 4 Contribution or participation in a conference

Symposium of Western Australian Neuroscience (SWAN)

Bhedita Seewoo (Participant)

26 Jun 2017

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Australasian Neuroscience Society (ANS) Annual Scientific Meeting

Bhedita Seewoo (Participant)

3 Dec 20176 Dec 2017

Activity: Conferences and workshopsContribution or participation in a conference

Australian Society for Medical Research (ASMR) Medical Research Week® Scientific Symposium

Bhedita Seewoo (Participant)

7 Jun 2017

Activity: Conferences and workshopsContribution or participation in a conference

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