Responses to bronchial challenge submitted for approval to use inhaled Beta 2-agonists before an event at the 2002 Winter Olympics

S.D. Anderson, Ken Fitch, C.P. Perry, M. Sue-Chu, R. Crapo, D. Mckenzie, H. Magnussen

    Research output: Contribution to journalArticle

    97 Citations (Scopus)

    Abstract

    Background: There has been an increase in the number and percentage of athletes competing in Olympic Games notifying Use Of beta(2)-agonists, from 1.7% at Los Angeles (1984) to 5.5% at Sydney (2000). For Salt Lake City (2002), the International Olympic Committee requested objective evidence to use beta(2)-agonists for asthma or exercise-induced asthma (EIA).Objective: The objective of this study was to evaluate the evidence submitted for approval to use a beta(2)-agonist.Methods: Objective evidence for asthma or EIA included (1) an increase of 12% or more of the predicted FEV1 in response to bronchodilator, (2) a reduction in FEV1 of 10% or greater from baseline in response to exercise or eucapnic voluntary hyperpnea, (3) a PD20 FEV1 to methacholine or histamine at a dose of less than 200 mug (2 mg/mL) or less than 1320 mug (13.2 mg/mL) for those taking inhaled corticosteroids for 3 months.Results: There were 165 applications. Of these, 147 (89%) included evidence of a challenge, bronchodilator response, or both, and 163 test results were submitted. One hundred thirty (5.2%) applications were approved. For those with positive responses, the median value (1) was 16.2% of predicted FEV1 for response to a bronchodilator (n = 13), (2) was a 15.9% decrease in FEV1 for response to a physical challenge (n = 36), and, (3) for PD20 FEV1 was 173 mug for response to a pharmacologic challenge (n = 45).Conclusion: The analysis demonstrated that it is feasible to request objective evidence to justify use of beta(2)-agonists on the medical grounds of asthma or EIA.
    Original languageEnglish
    Pages (from-to)45-50
    JournalJournal of Allergy and Clinical Immunology
    Volume111
    Issue number1
    DOIs
    Publication statusPublished - 2003

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