Response of the Rat Optic Nerve to Acute Intraocular and Intracranial Pressure Changes

Jeremiah Kah Heng Lim; Da Zhao; Zheng He; Anna K. van Koeverden; Algis Vingrys; Vickie H.Y. Wong; Christine T O Nguyen; Bang V Bui

doi:10.1007/978-981-13-2137-5_21

Response of the Rat Optic Nerve to Acute Intraocular and Intracranial Pressure Changes

Jeremiah Kah Heng Lim, Da Zhao, Zheng He, Anna K. van Koeverden, Algis Vingrys, Vickie H.Y. Wong, Christine T O Nguyen, Bang V Bui

Research output: Chapter in Book/Conference paper › Chapter › peer-review

Abstract

Glaucoma is a neurodegenerative disease, characterized by the progressive death of retinal ganglion cells. Elevated intraocular pressure (IOP) is known to be an important risk factor for glaucoma; however, it is not the only force acting on the optic nerve. Intracranial pressure (ICP) also exerts an effect on the optic nerve head, effectively opposing the force applied by IOP. Indeed, this balance of forces creates a pressure gradient (or the translaminar pressure gradient) across the optic nerve head [1]. Increasingly it is thought that the pressure difference between IOP and ICP, the translaminar pressure (TLP), may be critical for the integrity of the retina and optic nerve [2], and thus ICP may be an important risk factor for glaucoma [2–6].

Original language	English
Title of host publication	Intraocular and Intracranial Pressure Gradient in Glaucoma
Editors	N Wang
Place of Publication	Singapore
Publisher	Springer Nature Singapore Pte Ltd
Chapter	21
Pages	159–165
Volume	1
ISBN (Electronic)	978-981-13-2136-8
ISBN (Print)	978-981-13-2137-5
DOIs	https://doi.org/10.1007/978-981-13-2137-5_21
Publication status	E-pub ahead of print - 31 Mar 2019
Externally published	Yes

Publication series

Name	Advances in Visual Science and Eye Diseases

Access to Document

10.1007/978-981-13-2137-5_21

Cite this

Lim, J. K. H., Zhao, D., He, Z., van Koeverden, A. K., Vingrys, A., Wong, V. H. Y., Nguyen, C. T. O., & Bui, B. V. (2019). Response of the Rat Optic Nerve to Acute Intraocular and Intracranial Pressure Changes. In N. Wang (Ed.), Intraocular and Intracranial Pressure Gradient in Glaucoma (Vol. 1, pp. 159–165). (Advances in Visual Science and Eye Diseases ). Springer Nature Singapore Pte Ltd. Advance online publication. https://doi.org/10.1007/978-981-13-2137-5_21

@inbook{78ae694f2cae4c61bfb5295b7d115238,

title = "Response of the Rat Optic Nerve to Acute Intraocular and Intracranial Pressure Changes",

abstract = "Glaucoma is a neurodegenerative disease, characterized by the progressive death of retinal ganglion cells. Elevated intraocular pressure (IOP) is known to be an important risk factor for glaucoma; however, it is not the only force acting on the optic nerve. Intracranial pressure (ICP) also exerts an effect on the optic nerve head, effectively opposing the force applied by IOP. Indeed, this balance of forces creates a pressure gradient (or the translaminar pressure gradient) across the optic nerve head [1]. Increasingly it is thought that the pressure difference between IOP and ICP, the translaminar pressure (TLP), may be critical for the integrity of the retina and optic nerve [2], and thus ICP may be an important risk factor for glaucoma [2–6].",

author = "Lim, {Jeremiah Kah Heng} and Da Zhao and Zheng He and {van Koeverden}, {Anna K.} and Algis Vingrys and Wong, {Vickie H.Y.} and Nguyen, {Christine T O} and Bui, {Bang V}",

year = "2019",

month = mar,

day = "31",

doi = "10.1007/978-981-13-2137-5_21",

language = "English",

isbn = "978-981-13-2137-5",

volume = "1",

series = "Advances in Visual Science and Eye Diseases ",

publisher = "Springer Nature Singapore Pte Ltd",

pages = "159–165",

editor = "N Wang",

booktitle = "Intraocular and Intracranial Pressure Gradient in Glaucoma",

}

Lim, JKH, Zhao, D, He, Z, van Koeverden, AK, Vingrys, A, Wong, VHY, Nguyen, CTO & Bui, BV 2019, Response of the Rat Optic Nerve to Acute Intraocular and Intracranial Pressure Changes. in N Wang (ed.), Intraocular and Intracranial Pressure Gradient in Glaucoma. vol. 1, Advances in Visual Science and Eye Diseases , Springer Nature Singapore Pte Ltd, Singapore, pp. 159–165. https://doi.org/10.1007/978-981-13-2137-5_21

Response of the Rat Optic Nerve to Acute Intraocular and Intracranial Pressure Changes. / Lim, Jeremiah Kah Heng; Zhao, Da; He, Zheng et al.
Intraocular and Intracranial Pressure Gradient in Glaucoma. ed. / N Wang. Vol. 1 Singapore: Springer Nature Singapore Pte Ltd, 2019. p. 159–165 (Advances in Visual Science and Eye Diseases ).

Research output: Chapter in Book/Conference paper › Chapter › peer-review

TY - CHAP

T1 - Response of the Rat Optic Nerve to Acute Intraocular and Intracranial Pressure Changes

AU - Lim, Jeremiah Kah Heng

AU - Zhao, Da

AU - He, Zheng

AU - van Koeverden, Anna K.

AU - Vingrys, Algis

AU - Wong, Vickie H.Y.

AU - Nguyen, Christine T O

AU - Bui, Bang V

PY - 2019/3/31

Y1 - 2019/3/31

N2 - Glaucoma is a neurodegenerative disease, characterized by the progressive death of retinal ganglion cells. Elevated intraocular pressure (IOP) is known to be an important risk factor for glaucoma; however, it is not the only force acting on the optic nerve. Intracranial pressure (ICP) also exerts an effect on the optic nerve head, effectively opposing the force applied by IOP. Indeed, this balance of forces creates a pressure gradient (or the translaminar pressure gradient) across the optic nerve head [1]. Increasingly it is thought that the pressure difference between IOP and ICP, the translaminar pressure (TLP), may be critical for the integrity of the retina and optic nerve [2], and thus ICP may be an important risk factor for glaucoma [2–6].

AB - Glaucoma is a neurodegenerative disease, characterized by the progressive death of retinal ganglion cells. Elevated intraocular pressure (IOP) is known to be an important risk factor for glaucoma; however, it is not the only force acting on the optic nerve. Intracranial pressure (ICP) also exerts an effect on the optic nerve head, effectively opposing the force applied by IOP. Indeed, this balance of forces creates a pressure gradient (or the translaminar pressure gradient) across the optic nerve head [1]. Increasingly it is thought that the pressure difference between IOP and ICP, the translaminar pressure (TLP), may be critical for the integrity of the retina and optic nerve [2], and thus ICP may be an important risk factor for glaucoma [2–6].

U2 - 10.1007/978-981-13-2137-5_21

DO - 10.1007/978-981-13-2137-5_21

M3 - Chapter

SN - 978-981-13-2137-5

VL - 1

T3 - Advances in Visual Science and Eye Diseases

SP - 159

EP - 165

BT - Intraocular and Intracranial Pressure Gradient in Glaucoma

A2 - Wang, N

PB - Springer Nature Singapore Pte Ltd

CY - Singapore

ER -

Lim JKH, Zhao D, He Z, van Koeverden AK, Vingrys A, Wong VHY et al. Response of the Rat Optic Nerve to Acute Intraocular and Intracranial Pressure Changes. In Wang N, editor, Intraocular and Intracranial Pressure Gradient in Glaucoma. Vol. 1. Singapore: Springer Nature Singapore Pte Ltd. 2019. p. 159–165. (Advances in Visual Science and Eye Diseases ). Epub 2019 Mar 31. doi: 10.1007/978-981-13-2137-5_21

Response of the Rat Optic Nerve to Acute Intraocular and Intracranial Pressure Changes

Abstract

Publication series

Access to Document

Fingerprint

Cite this