Respiratory viral infections and host responses; insights from genomics

Niamh M. Troy, Anthony Bosco

Research output: Contribution to journalReview articlepeer-review

73 Citations (Scopus)

Abstract

Respiratory viral infections are a leading cause of disease and mortality. The severity of these illnesses can vary markedly from mild or asymptomatic upper airway infections to severe wheezing, bronchiolitis or pneumonia. In this article, we review the viral sensing pathways and organizing principles that govern the innate immune response to infection. Then, we reconstruct the molecular networks that differentiate symptomatic from asymptomatic respiratory viral infections, and identify the underlying molecular drivers of these networks. Finally, we discuss unique aspects of the biology and pathogenesis of infections with respiratory syncytial virus, rhinovirus and influenza, drawing on insights from genomics.

Original languageEnglish
Article number156
JournalRespiratory Research
Volume17
Issue number1
DOIs
Publication statusPublished - 21 Nov 2016

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