Respiratory allergen from house dust mite is present in human milk and primes for allergic sensitization in a mouse model of asthma

P Macchiaverni, A Rekima, M Turfkruyer, L Mascarell, S Airouche, P Moingeon, K Adel-Patient, A Condino-Neto, I Annesi-Maesano, S L Prescott, M K Tulic, V Verhasselt

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Abstract

    There is an urgent need to identify environmental risk and protective factors in early life for the prevention of allergy. Our study demonstrates the presence of respiratory allergen from house dust mite, Der p 1, in human breast milk. Der p 1 in milk is immunoreactive, present in similar amounts as dietary egg antigen, and can be found in breast milk from diverse regions of the world. In a mouse model of asthma, oral exposure to Der p through breast milk strongly promotes sensitization rather than protect the progeny as we reported with egg antigen. These data highlight that antigen administration to the neonate through the oral route may contribute to child allergic sensitization and have important implications for the design of studies assessing early oral antigen exposure for allergic disease prevention. The up-to-now unknown worldwide presence of respiratory allergen in maternal milk allows new interpretation and design of environmental control epidemiological studies for allergic disease prevention.

    Original languageEnglish
    Pages (from-to)395-398
    Number of pages4
    JournalAllergy: European Journal of Allergy and Clinical Immunology
    Volume69
    Issue number3
    DOIs
    Publication statusPublished - Mar 2014

    Fingerprint

    Dermatophagoides Antigens
    Human Milk
    Asthma
    Antigens
    Ovum
    Milk
    Allergens
    Epidemiologic Studies
    Hypersensitivity
    Mothers
    Newborn Infant
    Dermatophagoides pteronyssinus antigen p 1

    Cite this

    Macchiaverni, P ; Rekima, A ; Turfkruyer, M ; Mascarell, L ; Airouche, S ; Moingeon, P ; Adel-Patient, K ; Condino-Neto, A ; Annesi-Maesano, I ; Prescott, S L ; Tulic, M K ; Verhasselt, V. / Respiratory allergen from house dust mite is present in human milk and primes for allergic sensitization in a mouse model of asthma. In: Allergy: European Journal of Allergy and Clinical Immunology. 2014 ; Vol. 69, No. 3. pp. 395-398.
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    title = "Respiratory allergen from house dust mite is present in human milk and primes for allergic sensitization in a mouse model of asthma",
    abstract = "There is an urgent need to identify environmental risk and protective factors in early life for the prevention of allergy. Our study demonstrates the presence of respiratory allergen from house dust mite, Der p 1, in human breast milk. Der p 1 in milk is immunoreactive, present in similar amounts as dietary egg antigen, and can be found in breast milk from diverse regions of the world. In a mouse model of asthma, oral exposure to Der p through breast milk strongly promotes sensitization rather than protect the progeny as we reported with egg antigen. These data highlight that antigen administration to the neonate through the oral route may contribute to child allergic sensitization and have important implications for the design of studies assessing early oral antigen exposure for allergic disease prevention. The up-to-now unknown worldwide presence of respiratory allergen in maternal milk allows new interpretation and design of environmental control epidemiological studies for allergic disease prevention.",
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    author = "P Macchiaverni and A Rekima and M Turfkruyer and L Mascarell and S Airouche and P Moingeon and K Adel-Patient and A Condino-Neto and I Annesi-Maesano and Prescott, {S L} and Tulic, {M K} and V Verhasselt",
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    Respiratory allergen from house dust mite is present in human milk and primes for allergic sensitization in a mouse model of asthma. / Macchiaverni, P; Rekima, A; Turfkruyer, M; Mascarell, L; Airouche, S; Moingeon, P; Adel-Patient, K; Condino-Neto, A; Annesi-Maesano, I; Prescott, S L; Tulic, M K; Verhasselt, V.

    In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 69, No. 3, 03.2014, p. 395-398.

    Research output: Contribution to journalArticle

    TY - JOUR

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    AU - Macchiaverni, P

    AU - Rekima, A

    AU - Turfkruyer, M

    AU - Mascarell, L

    AU - Airouche, S

    AU - Moingeon, P

    AU - Adel-Patient, K

    AU - Condino-Neto, A

    AU - Annesi-Maesano, I

    AU - Prescott, S L

    AU - Tulic, M K

    AU - Verhasselt, V

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    AB - There is an urgent need to identify environmental risk and protective factors in early life for the prevention of allergy. Our study demonstrates the presence of respiratory allergen from house dust mite, Der p 1, in human breast milk. Der p 1 in milk is immunoreactive, present in similar amounts as dietary egg antigen, and can be found in breast milk from diverse regions of the world. In a mouse model of asthma, oral exposure to Der p through breast milk strongly promotes sensitization rather than protect the progeny as we reported with egg antigen. These data highlight that antigen administration to the neonate through the oral route may contribute to child allergic sensitization and have important implications for the design of studies assessing early oral antigen exposure for allergic disease prevention. The up-to-now unknown worldwide presence of respiratory allergen in maternal milk allows new interpretation and design of environmental control epidemiological studies for allergic disease prevention.

    KW - Allergens/immunology

    KW - Animals

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    KW - Asthma/immunology

    KW - Colostrum/immunology

    KW - Cysteine Endopeptidases/immunology

    KW - Environmental Exposure/adverse effects

    KW - Female

    KW - Humans

    KW - Milk, Human/immunology

    KW - Pregnancy

    KW - Pyroglyphidae/immunology

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    ER -