Resonant acoustic radiation force optical coherence elastography

W. Qi, R. Li, T. Ma, Jiawen Li, K. Kirk Shung, Q. Zhou, Z. Chen

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

We report on a resonant acoustic radiation force optical coherence elastography (ARF-OCE) technique that uses mechanical resonant frequency to characterize and identify tissues of different types. The linear dependency of the resonant frequency on the square root of Young's modulus was validated on silicone phantoms. Both the frequency response spectrum and the 3D imaging results from the agar phantoms with hard inclusions confirmed the feasibility of deploying the resonant frequency as a mechanical contrast for tissue imaging. Furthermore, the results of resonant ARF-OCE imaging of a post-mortem human coronary artery with atherosclerosis demonstrate the potential of the resonant ARF-OCE as a non-invasive method for imaging and characterizing vulnerable plaques. © 2013 AIP Publishing LLC.
Original languageEnglish
Pages (from-to)103704-1 - 103704-5
JournalApplied Physics Letters
Volume103
Issue number10
DOIs
Publication statusPublished - 2013

Fingerprint

sound waves
resonant frequencies
arteriosclerosis
silicones
arteries
frequency response
modulus of elasticity
inclusions

Cite this

Qi, W., Li, R., Ma, T., Li, J., Kirk Shung, K., Zhou, Q., & Chen, Z. (2013). Resonant acoustic radiation force optical coherence elastography. Applied Physics Letters, 103(10), 103704-1 - 103704-5. https://doi.org/10.1063/1.4820252
Qi, W. ; Li, R. ; Ma, T. ; Li, Jiawen ; Kirk Shung, K. ; Zhou, Q. ; Chen, Z. / Resonant acoustic radiation force optical coherence elastography. In: Applied Physics Letters. 2013 ; Vol. 103, No. 10. pp. 103704-1 - 103704-5.
@article{0573577d265c4297bcf3aa09aa814186,
title = "Resonant acoustic radiation force optical coherence elastography",
abstract = "We report on a resonant acoustic radiation force optical coherence elastography (ARF-OCE) technique that uses mechanical resonant frequency to characterize and identify tissues of different types. The linear dependency of the resonant frequency on the square root of Young's modulus was validated on silicone phantoms. Both the frequency response spectrum and the 3D imaging results from the agar phantoms with hard inclusions confirmed the feasibility of deploying the resonant frequency as a mechanical contrast for tissue imaging. Furthermore, the results of resonant ARF-OCE imaging of a post-mortem human coronary artery with atherosclerosis demonstrate the potential of the resonant ARF-OCE as a non-invasive method for imaging and characterizing vulnerable plaques. {\circledC} 2013 AIP Publishing LLC.",
author = "W. Qi and R. Li and T. Ma and Jiawen Li and {Kirk Shung}, K. and Q. Zhou and Z. Chen",
year = "2013",
doi = "10.1063/1.4820252",
language = "English",
volume = "103",
pages = "103704--1 -- 103704--5",
journal = "Applied Physics Letters",
issn = "0003-6951",
publisher = "ACOUSTICAL SOC AMER AMER INST PHYSICS",
number = "10",

}

Qi, W, Li, R, Ma, T, Li, J, Kirk Shung, K, Zhou, Q & Chen, Z 2013, 'Resonant acoustic radiation force optical coherence elastography' Applied Physics Letters, vol. 103, no. 10, pp. 103704-1 - 103704-5. https://doi.org/10.1063/1.4820252

Resonant acoustic radiation force optical coherence elastography. / Qi, W.; Li, R.; Ma, T.; Li, Jiawen; Kirk Shung, K.; Zhou, Q.; Chen, Z.

In: Applied Physics Letters, Vol. 103, No. 10, 2013, p. 103704-1 - 103704-5.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Resonant acoustic radiation force optical coherence elastography

AU - Qi, W.

AU - Li, R.

AU - Ma, T.

AU - Li, Jiawen

AU - Kirk Shung, K.

AU - Zhou, Q.

AU - Chen, Z.

PY - 2013

Y1 - 2013

N2 - We report on a resonant acoustic radiation force optical coherence elastography (ARF-OCE) technique that uses mechanical resonant frequency to characterize and identify tissues of different types. The linear dependency of the resonant frequency on the square root of Young's modulus was validated on silicone phantoms. Both the frequency response spectrum and the 3D imaging results from the agar phantoms with hard inclusions confirmed the feasibility of deploying the resonant frequency as a mechanical contrast for tissue imaging. Furthermore, the results of resonant ARF-OCE imaging of a post-mortem human coronary artery with atherosclerosis demonstrate the potential of the resonant ARF-OCE as a non-invasive method for imaging and characterizing vulnerable plaques. © 2013 AIP Publishing LLC.

AB - We report on a resonant acoustic radiation force optical coherence elastography (ARF-OCE) technique that uses mechanical resonant frequency to characterize and identify tissues of different types. The linear dependency of the resonant frequency on the square root of Young's modulus was validated on silicone phantoms. Both the frequency response spectrum and the 3D imaging results from the agar phantoms with hard inclusions confirmed the feasibility of deploying the resonant frequency as a mechanical contrast for tissue imaging. Furthermore, the results of resonant ARF-OCE imaging of a post-mortem human coronary artery with atherosclerosis demonstrate the potential of the resonant ARF-OCE as a non-invasive method for imaging and characterizing vulnerable plaques. © 2013 AIP Publishing LLC.

U2 - 10.1063/1.4820252

DO - 10.1063/1.4820252

M3 - Article

VL - 103

SP - 103704-1 - 103704-5

JO - Applied Physics Letters

JF - Applied Physics Letters

SN - 0003-6951

IS - 10

ER -

Qi W, Li R, Ma T, Li J, Kirk Shung K, Zhou Q et al. Resonant acoustic radiation force optical coherence elastography. Applied Physics Letters. 2013;103(10):103704-1 - 103704-5. https://doi.org/10.1063/1.4820252