Replicating genotype-phenotype associations : What constitutes replication of a genotype–phenotype association, and how best can it be achieved?

S.J. Chanock; T. Manolio; M. Boehnke; E. Boerwinkle; D.J. Hunter; G. Thomas; J.N. Hirschorn; G. Abecasis; D. Altshuler; J.E. Bailey-Wilson; L.D. Brooks; L.R. Cardon; M. Daly; P. Donnelly; J.F. Fraumeni Jr; N.B. Freimer; D.S. Gerhard; C. Gunter; A.E. Guttmacher; M.S. Guyer; E.L. Harris; J. Hoh; R. Hoover; C.A. Kong; K.R. Merikangas; C.C. Mortin; Lyle Palmer; E.G. Phimister; J.P. Rice; J. Roberts; C.H. Rotimi; M.A. Tucker; K.J. Vogan; S. Wacholder; E.M. Wijsman; D.M. Winn; F.S. Collins

doi:10.1038/447655a

Replicating genotype-phenotype associations : What constitutes replication of a genotype–phenotype association, and how best can it be achieved?

S.J. Chanock, T. Manolio, M. Boehnke, E. Boerwinkle, D.J. Hunter, G. Thomas, J.N. Hirschorn, G. Abecasis, D. Altshuler, J.E. Bailey-Wilson, L.D. Brooks, L.R. Cardon, M. Daly, P. Donnelly, J.F. Fraumeni Jr, N.B. Freimer, D.S. Gerhard, C. Gunter, A.E. Guttmacher, M.S. GuyerE.L. Harris, J. Hoh, R. Hoover, C.A. Kong, K.R. Merikangas, C.C. Mortin, Lyle Palmer, E.G. Phimister, J.P. Rice, J. Roberts, C.H. Rotimi, M.A. Tucker, K.J. Vogan, S. Wacholder, E.M. Wijsman, D.M. Winn, F.S. Collins

Research output: Contribution to journal › Article › peer-review

1174 Citations (Scopus)

Original language	English
Pages (from-to)	655-660
Journal	Nature
Volume	447
DOIs	https://doi.org/10.1038/447655a
Publication status	Published - 2007

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Chanock, S. J., Manolio, T., Boehnke, M., Boerwinkle, E., Hunter, D. J., Thomas, G., Hirschorn, J. N., Abecasis, G., Altshuler, D., Bailey-Wilson, J. E., Brooks, L. D., Cardon, L. R., Daly, M., Donnelly, P., Fraumeni Jr, J. F., Freimer, N. B., Gerhard, D. S., Gunter, C., Guttmacher, A. E., ... Collins, F. S. (2007). Replicating genotype-phenotype associations : What constitutes replication of a genotype–phenotype association, and how best can it be achieved? Nature, 447, 655-660. https://doi.org/10.1038/447655a

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title = "Replicating genotype-phenotype associations : What constitutes replication of a genotype–phenotype association, and how best can it be achieved?",

author = "S.J. Chanock and T. Manolio and M. Boehnke and E. Boerwinkle and D.J. Hunter and G. Thomas and J.N. Hirschorn and G. Abecasis and D. Altshuler and J.E. Bailey-Wilson and L.D. Brooks and L.R. Cardon and M. Daly and P. Donnelly and {Fraumeni Jr}, J.F. and N.B. Freimer and D.S. Gerhard and C. Gunter and A.E. Guttmacher and M.S. Guyer and E.L. Harris and J. Hoh and R. Hoover and C.A. Kong and K.R. Merikangas and C.C. Mortin and Lyle Palmer and E.G. Phimister and J.P. Rice and J. Roberts and C.H. Rotimi and M.A. Tucker and K.J. Vogan and S. Wacholder and E.M. Wijsman and D.M. Winn and F.S. Collins",

year = "2007",

doi = "10.1038/447655a",

language = "English",

volume = "447",

pages = "655--660",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group - Macmillan Publishers",

}

Chanock, SJ, Manolio, T, Boehnke, M, Boerwinkle, E, Hunter, DJ, Thomas, G, Hirschorn, JN, Abecasis, G, Altshuler, D, Bailey-Wilson, JE, Brooks, LD, Cardon, LR, Daly, M, Donnelly, P, Fraumeni Jr, JF, Freimer, NB, Gerhard, DS, Gunter, C, Guttmacher, AE, Guyer, MS, Harris, EL, Hoh, J, Hoover, R, Kong, CA, Merikangas, KR, Mortin, CC, Palmer, L, Phimister, EG, Rice, JP, Roberts, J, Rotimi, CH, Tucker, MA, Vogan, KJ, Wacholder, S, Wijsman, EM, Winn, DM & Collins, FS 2007, 'Replicating genotype-phenotype associations : What constitutes replication of a genotype–phenotype association, and how best can it be achieved?', Nature, vol. 447, pp. 655-660. https://doi.org/10.1038/447655a