Renal Denervation Update From the International Sympathetic Nervous System Summit

Marcio G. Kiuchi, Murray D. Esler, Gregory D. Fink, John W. Osborn, Christopher T. Banek, Michael Boehm, Kate M. Denton, Gerald F. DiBona, Thomas H. Everett, Guido Grassi, Richard E. Katholi, Mark M. Knuepfer, Ulla C. Kopp, David J. Lefer, Thomas E. Lohmeier, Clive N. May, Felix Mahfoud, Julian F. R. Paton, Roland E. Schmieder, Peter R. Pellegrino & 2 others Yehonatan Sharabi, Markus P. Schlaich

Research output: Contribution to journalReview article

Abstract

Three recent renal denervation studies in both drug-naive and drug-treated hypertensive patients demonstrated a significant reduction of ambulatory blood pressure compared with respective sham control groups. Improved trial design, selection of relevant patient cohorts, and optimized interventional procedures have likely contributed to these positive findings. However, substantial variability in the blood pressure response to renal denervation can still be observed and remains a challenging and important problem. The International Sympathetic Nervous System Summit was convened to bring together experts in both experimental and clinical medicine to discuss the current evidence base, novel developments in our understanding of neural interplay, procedural aspects, monitoring of technical success, and others. Identification of relevant trends in the field and initiation of tailored and combined experimental and clinical research efforts will help to address remaining questions and provide much-needed evidence to guide clinical use of renal denervation for hypertension treatment and other potential indications. (C) 2019 by the American College of Cardiology Foundation.

Original languageEnglish
Pages (from-to)3006-3017
Number of pages12
JournalJournal of the American College of Cardiology
Volume73
Issue number23
DOIs
Publication statusPublished - 18 Jun 2019

Cite this

Kiuchi, Marcio G. ; Esler, Murray D. ; Fink, Gregory D. ; Osborn, John W. ; Banek, Christopher T. ; Boehm, Michael ; Denton, Kate M. ; DiBona, Gerald F. ; Everett, Thomas H. ; Grassi, Guido ; Katholi, Richard E. ; Knuepfer, Mark M. ; Kopp, Ulla C. ; Lefer, David J. ; Lohmeier, Thomas E. ; May, Clive N. ; Mahfoud, Felix ; Paton, Julian F. R. ; Schmieder, Roland E. ; Pellegrino, Peter R. ; Sharabi, Yehonatan ; Schlaich, Markus P. / Renal Denervation Update From the International Sympathetic Nervous System Summit. In: Journal of the American College of Cardiology. 2019 ; Vol. 73, No. 23. pp. 3006-3017.
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abstract = "Three recent renal denervation studies in both drug-naive and drug-treated hypertensive patients demonstrated a significant reduction of ambulatory blood pressure compared with respective sham control groups. Improved trial design, selection of relevant patient cohorts, and optimized interventional procedures have likely contributed to these positive findings. However, substantial variability in the blood pressure response to renal denervation can still be observed and remains a challenging and important problem. The International Sympathetic Nervous System Summit was convened to bring together experts in both experimental and clinical medicine to discuss the current evidence base, novel developments in our understanding of neural interplay, procedural aspects, monitoring of technical success, and others. Identification of relevant trends in the field and initiation of tailored and combined experimental and clinical research efforts will help to address remaining questions and provide much-needed evidence to guide clinical use of renal denervation for hypertension treatment and other potential indications. (C) 2019 by the American College of Cardiology Foundation.",
keywords = "blood pressure, cardiovascular disease, hypertension, renal denervation, sympathetic nervous system, BLOOD-PRESSURE RESPONSE, ANTIHYPERTENSIVE TREATMENT, RESISTANT HYPERTENSION, SPINAL-CORD, INFLAMMATION, NEURONS, STELLATE, AFFERENT, NERVES, BRAIN",
author = "Kiuchi, {Marcio G.} and Esler, {Murray D.} and Fink, {Gregory D.} and Osborn, {John W.} and Banek, {Christopher T.} and Michael Boehm and Denton, {Kate M.} and DiBona, {Gerald F.} and Everett, {Thomas H.} and Guido Grassi and Katholi, {Richard E.} and Knuepfer, {Mark M.} and Kopp, {Ulla C.} and Lefer, {David J.} and Lohmeier, {Thomas E.} and May, {Clive N.} and Felix Mahfoud and Paton, {Julian F. R.} and Schmieder, {Roland E.} and Pellegrino, {Peter R.} and Yehonatan Sharabi and Schlaich, {Markus P.}",
year = "2019",
month = "6",
day = "18",
doi = "10.1016/j.jacc.2019.04.015",
language = "English",
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pages = "3006--3017",
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Kiuchi, MG, Esler, MD, Fink, GD, Osborn, JW, Banek, CT, Boehm, M, Denton, KM, DiBona, GF, Everett, TH, Grassi, G, Katholi, RE, Knuepfer, MM, Kopp, UC, Lefer, DJ, Lohmeier, TE, May, CN, Mahfoud, F, Paton, JFR, Schmieder, RE, Pellegrino, PR, Sharabi, Y & Schlaich, MP 2019, 'Renal Denervation Update From the International Sympathetic Nervous System Summit' Journal of the American College of Cardiology, vol. 73, no. 23, pp. 3006-3017. https://doi.org/10.1016/j.jacc.2019.04.015

Renal Denervation Update From the International Sympathetic Nervous System Summit. / Kiuchi, Marcio G.; Esler, Murray D.; Fink, Gregory D.; Osborn, John W.; Banek, Christopher T.; Boehm, Michael; Denton, Kate M.; DiBona, Gerald F.; Everett, Thomas H.; Grassi, Guido; Katholi, Richard E.; Knuepfer, Mark M.; Kopp, Ulla C.; Lefer, David J.; Lohmeier, Thomas E.; May, Clive N.; Mahfoud, Felix; Paton, Julian F. R.; Schmieder, Roland E.; Pellegrino, Peter R.; Sharabi, Yehonatan; Schlaich, Markus P.

In: Journal of the American College of Cardiology, Vol. 73, No. 23, 18.06.2019, p. 3006-3017.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Renal Denervation Update From the International Sympathetic Nervous System Summit

AU - Kiuchi, Marcio G.

AU - Esler, Murray D.

AU - Fink, Gregory D.

AU - Osborn, John W.

AU - Banek, Christopher T.

AU - Boehm, Michael

AU - Denton, Kate M.

AU - DiBona, Gerald F.

AU - Everett, Thomas H.

AU - Grassi, Guido

AU - Katholi, Richard E.

AU - Knuepfer, Mark M.

AU - Kopp, Ulla C.

AU - Lefer, David J.

AU - Lohmeier, Thomas E.

AU - May, Clive N.

AU - Mahfoud, Felix

AU - Paton, Julian F. R.

AU - Schmieder, Roland E.

AU - Pellegrino, Peter R.

AU - Sharabi, Yehonatan

AU - Schlaich, Markus P.

PY - 2019/6/18

Y1 - 2019/6/18

N2 - Three recent renal denervation studies in both drug-naive and drug-treated hypertensive patients demonstrated a significant reduction of ambulatory blood pressure compared with respective sham control groups. Improved trial design, selection of relevant patient cohorts, and optimized interventional procedures have likely contributed to these positive findings. However, substantial variability in the blood pressure response to renal denervation can still be observed and remains a challenging and important problem. The International Sympathetic Nervous System Summit was convened to bring together experts in both experimental and clinical medicine to discuss the current evidence base, novel developments in our understanding of neural interplay, procedural aspects, monitoring of technical success, and others. Identification of relevant trends in the field and initiation of tailored and combined experimental and clinical research efforts will help to address remaining questions and provide much-needed evidence to guide clinical use of renal denervation for hypertension treatment and other potential indications. (C) 2019 by the American College of Cardiology Foundation.

AB - Three recent renal denervation studies in both drug-naive and drug-treated hypertensive patients demonstrated a significant reduction of ambulatory blood pressure compared with respective sham control groups. Improved trial design, selection of relevant patient cohorts, and optimized interventional procedures have likely contributed to these positive findings. However, substantial variability in the blood pressure response to renal denervation can still be observed and remains a challenging and important problem. The International Sympathetic Nervous System Summit was convened to bring together experts in both experimental and clinical medicine to discuss the current evidence base, novel developments in our understanding of neural interplay, procedural aspects, monitoring of technical success, and others. Identification of relevant trends in the field and initiation of tailored and combined experimental and clinical research efforts will help to address remaining questions and provide much-needed evidence to guide clinical use of renal denervation for hypertension treatment and other potential indications. (C) 2019 by the American College of Cardiology Foundation.

KW - blood pressure

KW - cardiovascular disease

KW - hypertension

KW - renal denervation

KW - sympathetic nervous system

KW - BLOOD-PRESSURE RESPONSE

KW - ANTIHYPERTENSIVE TREATMENT

KW - RESISTANT HYPERTENSION

KW - SPINAL-CORD

KW - INFLAMMATION

KW - NEURONS

KW - STELLATE

KW - AFFERENT

KW - NERVES

KW - BRAIN

U2 - 10.1016/j.jacc.2019.04.015

DO - 10.1016/j.jacc.2019.04.015

M3 - Review article

VL - 73

SP - 3006

EP - 3017

JO - Journal of American College of Cardiology

JF - Journal of American College of Cardiology

SN - 0735-1097

IS - 23

ER -