TY - JOUR
T1 - Renal cell carcinoma to haemangioblastoma metastasis
T2 - A rare manifestation of von Hippel-Lindau syndrome
AU - Dessauvagie, Benjamin F.
AU - Wong, George Tse Hwai
AU - Robbins, P. D.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Brain metastases are the most common intracranial malignancy in adults and may occasionally deposit within a pre-existing primary brain neoplasm. We describe, in two directly related family members, the rare occurrence of renal cell carcinoma (RCC) metastasis to haemangioblastoma (HB) in the context of Von Hippel-Lindau syndrome. Detection of this phenomenon can be marred by histological overlap between RCC and HB and therefore careful histological examination, and consideration of supportive immunohistochemistry, is required when examining all HB resections. Metastatic RCC to HB upstages a primary RCC and is clinically diagnostic of Von Hippel-Lindau syndrome.
AB - Brain metastases are the most common intracranial malignancy in adults and may occasionally deposit within a pre-existing primary brain neoplasm. We describe, in two directly related family members, the rare occurrence of renal cell carcinoma (RCC) metastasis to haemangioblastoma (HB) in the context of Von Hippel-Lindau syndrome. Detection of this phenomenon can be marred by histological overlap between RCC and HB and therefore careful histological examination, and consideration of supportive immunohistochemistry, is required when examining all HB resections. Metastatic RCC to HB upstages a primary RCC and is clinically diagnostic of Von Hippel-Lindau syndrome.
KW - Haemangioblastoma
KW - Metastasis
KW - Renal cell carcinoma
KW - Tumour-to-tumour metastasis
KW - Von Hippel-Lindau syndrome
UR - http://www.scopus.com/inward/record.url?scp=84920749312&partnerID=8YFLogxK
U2 - 10.1016/j.jocn.2014.04.024
DO - 10.1016/j.jocn.2014.04.024
M3 - Article
C2 - 25088480
AN - SCOPUS:84920749312
SN - 0967-5868
VL - 22
SP - 215
EP - 218
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
IS - 1
ER -