Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy

Bo He, Anna Johansson-Percival, Joseph Backhouse, Ji Li, Gabriel Yin Foo Lee, Juliana Hamzah, Ruth Ganss

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Treatment options for metastatic cancer are limited. He et al. develop a cytokine therapy that specifically targets leaky blood vessels in the pre-metastatic niche and established lung metastases. Treatment repairs vessel leakiness, prevents outgrowth of circulating cancer cells, and also sensitizes already established lung metastases for checkpoint inhibition.

Original languageEnglish
Pages (from-to)714-724.e5
JournalCell Reports
Volume30
Issue number3
DOIs
Publication statusPublished - 21 Jan 2020

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