Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy

Bo He; Anna Johansson-Percival; Joseph Backhouse; Ji Li; Gabriel Yin Foo Lee; Juliana Hamzah; Ruth Ganss

doi:10.1016/j.celrep.2019.12.013

Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy

Bo He, Anna Johansson-Percival, Joseph Backhouse, Ji Li, Gabriel Yin Foo Lee, Juliana Hamzah, Ruth Ganss

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Treatment options for metastatic cancer are limited. He et al. develop a cytokine therapy that specifically targets leaky blood vessels in the pre-metastatic niche and established lung metastases. Treatment repairs vessel leakiness, prevents outgrowth of circulating cancer cells, and also sensitizes already established lung metastases for checkpoint inhibition.

Original language	English
Pages (from-to)	714-724.e5
Journal	Cell Reports
Volume	30
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2019.12.013
Publication status	Published - 21 Jan 2020

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10.1016/j.celrep.2019.12.013Licence: CC BY-NC-ND

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title = "Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy",

abstract = "Treatment options for metastatic cancer are limited. He et al. develop a cytokine therapy that specifically targets leaky blood vessels in the pre-metastatic niche and established lung metastases. Treatment repairs vessel leakiness, prevents outgrowth of circulating cancer cells, and also sensitizes already established lung metastases for checkpoint inhibition.",

keywords = "angiogenesis, high endothelial venules, immunotherapy, metastasis, peptide tumor targeting, pre-metastatic niche, tertiary lymph node structures, vessel normalization",

author = "Bo He and Anna Johansson-Percival and Joseph Backhouse and Ji Li and Lee, {Gabriel Yin Foo} and Juliana Hamzah and Ruth Ganss",

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AU - He, Bo

AU - Johansson-Percival, Anna

AU - Backhouse, Joseph

AU - Li, Ji

AU - Lee, Gabriel Yin Foo

AU - Hamzah, Juliana

AU - Ganss, Ruth

PY - 2020/1/21

Y1 - 2020/1/21

N2 - Treatment options for metastatic cancer are limited. He et al. develop a cytokine therapy that specifically targets leaky blood vessels in the pre-metastatic niche and established lung metastases. Treatment repairs vessel leakiness, prevents outgrowth of circulating cancer cells, and also sensitizes already established lung metastases for checkpoint inhibition.

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KW - angiogenesis

KW - high endothelial venules

KW - immunotherapy

KW - metastasis

KW - peptide tumor targeting

KW - pre-metastatic niche

KW - tertiary lymph node structures

KW - vessel normalization

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ER -

Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy

Abstract

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Improving anti-cancer therapy by stromal targeting and remodelling

Improving anti-cancer therapy by vascular targeting and remodelling

Targeting inflammatory macrophages and blood vessels in atherosclerotic plagues for imaging and therapy

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Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy

Abstract

UN SDGs

Access to Document

Other files and links

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Projects

Improving anti-cancer therapy by stromal targeting and remodelling

Improving anti-cancer therapy by vascular targeting and remodelling

Targeting inflammatory macrophages and blood vessels in atherosclerotic plagues for imaging and therapy

Cite this