Remission of peanut allergy is associated with rewiring of allergen-driven T helper 2-related gene networks

Sarah E. Ashley, Anya C. Jones, Denise Anderson, Patrick G. Holt, Anthony Bosco, Mimi L.K. Tang

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Background: The immunological changes underpinning acquisition of remission (also called sustained unresponsiveness) following food immunotherapy remain poorly defined. Limited access to effective therapies and biosamples from treatment responders has prevented progress. Probiotic peanut oral immunotherapy is highly effective at inducing remission, providing an opportunity to investigate immune changes. Methods: Using a systems biology approach, we examined gene co-expression network patterns in peanut-specific CD4+ T cell responses before and after probiotic and peanut oral immunotherapy in subjects enrolled in the PPOIT-001 randomized trial: Responders who attained remission (n = 16), placebo-treated who remained allergic (n = 16). Results: Acquisition of remission was associated with rewiring of gene network patterns, which was characterized by integration of T helper 2 and interferon signalling modules, markedly reduced T helper 2 gene connectivity, and shutdown in co-expression activity between T helper 2 effectors and cell cycle regulators. Conclusion: The immunological changes underlying remission following peanut oral immunotherapy are mediated by reprogramming of T helper 2-associated gene networks in the CD4+ T cell compartment. Findings provide insight into immune mechanisms driving the acquisition of remission following oral immunotherapy, paving the way for the development of improved approaches to induce remission/sustained unresponsiveness in patients with food allergy.

Original languageEnglish
Pages (from-to)3015-3027
Number of pages13
JournalAllergy: European Journal of Allergy and Clinical Immunology
Issue number10
Early online date2022
Publication statusPublished - Oct 2022


Dive into the research topics of 'Remission of peanut allergy is associated with rewiring of allergen-driven T helper 2-related gene networks'. Together they form a unique fingerprint.

Cite this