Remineralizing potential of CPP-ACP applied for 1 min in vitro

Vaishnavi Gopalakrishnan, Robert P. Anthonappa, N.M. King, A. Itthagarun

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


© 2016, European Academy of Paediatric Dentistry.Aim: To evaluate (1) the remineralizing potential of Tooth Mousse® (TM) on artificial carious lesions, when applied for 1 min, and (2) the benefit of a fluoridated dentifrice prior to TM application. Methods: Demineralisation caries-like lesions 120–200 µm deep were produced by placing molars in demineralizing solution for 96 h, sections 100–150 µm thick were then randomly assigned to four groups. Specimens were treated thrice daily with a non-fluoridated (Group A), or fluoridated dentifrice (1000 ppm) (Group B), or TM (Group C), or a fluoridated dentifrice followed by TM (Group D) then subjected to a 10-day pH cycling model. Lesion evaluation involved polarizing light microscopy and microradiography. Results: Application of TM in isolation (Group C) for 1 min resulted in significant increase in lesion depth (LD), however, an increase in mineral content deposition (Vmax) was not significant. Post treatment LD increases were greatest in Group A, then Group C and Group B respectively. A decrease in LD (by 19.9 %) was noted only after fluoridated dentifrice and TM (Group D) were applied consecutively for 1 min each (p <0.05). Mineral content deposition was also greatest in this group (Group D) and both Vmax and LD changes were statistically significant when compared to other groups. Conclusions: TM alone failed to remineralize carious lesions when applied for 1 min. However, remineralization occurred after a prior application of a fluoridated dentifrice.
Original languageEnglish
Pages (from-to)231-237
Number of pages7
JournalEuropean Archives of Paediatric Dentistry
Issue number4
Publication statusPublished - 1 Aug 2016


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