Relevance of Targeting the Distal Renal Artery and Branches with Radiofrequency Renal Denervation ApproachesA Secondary Analysis from a Hypertensive CKD Patient Cohort

Marcio Galindo Kiuchi, Markus P. Schlaich, Shaojie Chen, Humberto Villacorta, Jan K. Ho, Revathy Carnagarin, Vance B. Matthews, Jocemir Ronaldo Lugon

Research output: Contribution to journalArticle

Abstract

We searched for an association between changes in blood pressure (BP) at 12 and 24 months after renal denervation (RDN) and the different patterns of ablation spots placement along the renal artery vasculature. We performed a post-hoc analysis of a 24-month follow-up evaluation of 30 patients who underwent RDN between 2011 and 2012 using our previous database. Patients who had (i) resistant hypertension, as meticulously described previously, and (ii) Chronic kidney disease (CKD) stages 2, 3 and 4. Correlations were assessed using the Pearson or Spearman correlation tests as appropriate. The mean change in systolic ambulatory BP monitoring (ABPM) compared to baseline was -19.4 +/- 12.7 mmHg at the 12th (p <0.0001) and -21.3 +/- 14.1 mmHg at the 24th month (p <0.0001). There was no correlation between the ABPM Systolic Blood Pressure (SBP)-lowering effect and the total number of ablated spots in renal arteries (17.7 +/- 6.0) either at 12 (r = -0.3, p = 0.1542) or at 24 months (r = -0.2, p = 0.4009). However, correlations between systolic BP-lowering effect and the number of ablation spots performed in the distal segment and branches were significant at the 12 (r = -0.7, p <0.0001) and 24 months (r = -0.8, p <0.0001) follow-up. Our findings indicate a substantial correlation between the numbers of ablated sites in the distal segment and branches of renal arteries and the systolic BP-lowering effect in the long-term.

Original languageEnglish
Article number581
Number of pages16
JournalJournal of Clinical Medicine
Volume8
Issue number5
DOIs
Publication statusPublished - May 2019

Cite this

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title = "Relevance of Targeting the Distal Renal Artery and Branches with Radiofrequency Renal Denervation ApproachesA Secondary Analysis from a Hypertensive CKD Patient Cohort",
abstract = "We searched for an association between changes in blood pressure (BP) at 12 and 24 months after renal denervation (RDN) and the different patterns of ablation spots placement along the renal artery vasculature. We performed a post-hoc analysis of a 24-month follow-up evaluation of 30 patients who underwent RDN between 2011 and 2012 using our previous database. Patients who had (i) resistant hypertension, as meticulously described previously, and (ii) Chronic kidney disease (CKD) stages 2, 3 and 4. Correlations were assessed using the Pearson or Spearman correlation tests as appropriate. The mean change in systolic ambulatory BP monitoring (ABPM) compared to baseline was -19.4 +/- 12.7 mmHg at the 12th (p <0.0001) and -21.3 +/- 14.1 mmHg at the 24th month (p <0.0001). There was no correlation between the ABPM Systolic Blood Pressure (SBP)-lowering effect and the total number of ablated spots in renal arteries (17.7 +/- 6.0) either at 12 (r = -0.3, p = 0.1542) or at 24 months (r = -0.2, p = 0.4009). However, correlations between systolic BP-lowering effect and the number of ablation spots performed in the distal segment and branches were significant at the 12 (r = -0.7, p <0.0001) and 24 months (r = -0.8, p <0.0001) follow-up. Our findings indicate a substantial correlation between the numbers of ablated sites in the distal segment and branches of renal arteries and the systolic BP-lowering effect in the long-term.",
keywords = "hypertension, chronic kidney disease, renal denervation, blood pressure reduction, sympathetic nervous system, SYMPATHETIC-NERVOUS-SYSTEM, CHRONIC KIDNEY-DISEASE, EUROPEAN-SOCIETY, BLOOD-PRESSURE, CATHETER, ABLATION, NERVES, CARDIOLOGY, TRIAL",
author = "Kiuchi, {Marcio Galindo} and Schlaich, {Markus P.} and Shaojie Chen and Humberto Villacorta and Ho, {Jan K.} and Revathy Carnagarin and Matthews, {Vance B.} and Lugon, {Jocemir Ronaldo}",
year = "2019",
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language = "English",
volume = "8",
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Relevance of Targeting the Distal Renal Artery and Branches with Radiofrequency Renal Denervation ApproachesA Secondary Analysis from a Hypertensive CKD Patient Cohort. / Kiuchi, Marcio Galindo; Schlaich, Markus P.; Chen, Shaojie; Villacorta, Humberto; Ho, Jan K.; Carnagarin, Revathy; Matthews, Vance B.; Lugon, Jocemir Ronaldo.

In: Journal of Clinical Medicine, Vol. 8, No. 5, 581, 05.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relevance of Targeting the Distal Renal Artery and Branches with Radiofrequency Renal Denervation ApproachesA Secondary Analysis from a Hypertensive CKD Patient Cohort

AU - Kiuchi, Marcio Galindo

AU - Schlaich, Markus P.

AU - Chen, Shaojie

AU - Villacorta, Humberto

AU - Ho, Jan K.

AU - Carnagarin, Revathy

AU - Matthews, Vance B.

AU - Lugon, Jocemir Ronaldo

PY - 2019/5

Y1 - 2019/5

N2 - We searched for an association between changes in blood pressure (BP) at 12 and 24 months after renal denervation (RDN) and the different patterns of ablation spots placement along the renal artery vasculature. We performed a post-hoc analysis of a 24-month follow-up evaluation of 30 patients who underwent RDN between 2011 and 2012 using our previous database. Patients who had (i) resistant hypertension, as meticulously described previously, and (ii) Chronic kidney disease (CKD) stages 2, 3 and 4. Correlations were assessed using the Pearson or Spearman correlation tests as appropriate. The mean change in systolic ambulatory BP monitoring (ABPM) compared to baseline was -19.4 +/- 12.7 mmHg at the 12th (p <0.0001) and -21.3 +/- 14.1 mmHg at the 24th month (p <0.0001). There was no correlation between the ABPM Systolic Blood Pressure (SBP)-lowering effect and the total number of ablated spots in renal arteries (17.7 +/- 6.0) either at 12 (r = -0.3, p = 0.1542) or at 24 months (r = -0.2, p = 0.4009). However, correlations between systolic BP-lowering effect and the number of ablation spots performed in the distal segment and branches were significant at the 12 (r = -0.7, p <0.0001) and 24 months (r = -0.8, p <0.0001) follow-up. Our findings indicate a substantial correlation between the numbers of ablated sites in the distal segment and branches of renal arteries and the systolic BP-lowering effect in the long-term.

AB - We searched for an association between changes in blood pressure (BP) at 12 and 24 months after renal denervation (RDN) and the different patterns of ablation spots placement along the renal artery vasculature. We performed a post-hoc analysis of a 24-month follow-up evaluation of 30 patients who underwent RDN between 2011 and 2012 using our previous database. Patients who had (i) resistant hypertension, as meticulously described previously, and (ii) Chronic kidney disease (CKD) stages 2, 3 and 4. Correlations were assessed using the Pearson or Spearman correlation tests as appropriate. The mean change in systolic ambulatory BP monitoring (ABPM) compared to baseline was -19.4 +/- 12.7 mmHg at the 12th (p <0.0001) and -21.3 +/- 14.1 mmHg at the 24th month (p <0.0001). There was no correlation between the ABPM Systolic Blood Pressure (SBP)-lowering effect and the total number of ablated spots in renal arteries (17.7 +/- 6.0) either at 12 (r = -0.3, p = 0.1542) or at 24 months (r = -0.2, p = 0.4009). However, correlations between systolic BP-lowering effect and the number of ablation spots performed in the distal segment and branches were significant at the 12 (r = -0.7, p <0.0001) and 24 months (r = -0.8, p <0.0001) follow-up. Our findings indicate a substantial correlation between the numbers of ablated sites in the distal segment and branches of renal arteries and the systolic BP-lowering effect in the long-term.

KW - hypertension

KW - chronic kidney disease

KW - renal denervation

KW - blood pressure reduction

KW - sympathetic nervous system

KW - SYMPATHETIC-NERVOUS-SYSTEM

KW - CHRONIC KIDNEY-DISEASE

KW - EUROPEAN-SOCIETY

KW - BLOOD-PRESSURE

KW - CATHETER

KW - ABLATION

KW - NERVES

KW - CARDIOLOGY

KW - TRIAL

U2 - 10.3390/jcm8050581

DO - 10.3390/jcm8050581

M3 - Article

VL - 8

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

SN - 2077-0383

IS - 5

M1 - 581

ER -