Relationships between plasma concentrations of leptin and other metabolic hormones in GH-transgenic sheep infused with glucose

H. Kadokawa, J.R. Briegel, Margaret Blackberry, Dominique Blache, Graeme Martin, N.R. Adams

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

To study the regulation of leptin secretion in sheep, we infused glucose (0.32 g/h/kg for 12 h) intoGH-transgenic animals (n = 8) that have chronically high plasma concentrations of ovine GH andinsulin, but low body condition and low plasma leptin concentrations, and compared the responseswith those in controls (n = 8). In both groups, the infusion increased plasma concentrations ofglucose and insulin within 1 h and maintained high levels throughout the infusion period (P
Original languageEnglish
Pages (from-to)219-229
JournalDomestic Animal Endocrinology
Volume24
Issue number3
DOIs
Publication statusPublished - 2003

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