Projects per year
Abstract
Background: There is now good evidence that events during gestation significantly influence the developmental well-being of an individual in later life. This study aimed to investigate the relationships between intrauterine growth trajectories determined by serial ultrasound and subsequent markers of adiposity and inflammation in the 27-year-old adult offspring from the Raine Study, an Australian longitudinal pregnancy cohort. Methods: Ultrasound fetal biometric measurements including abdominal circumference (AC), femur length (FL), and head circumference (HC) from 1333 mother-fetal pairs (Gen1–Gen2) in the Raine Study were used to develop fetal growth trajectories using group-based trajectory modeling. Linear mixed modeling investigated the relationship between adult body mass index (BMI), waist circumference (WC), and high-sensitivity C-reactive protein (hs-CRP) of Gen2 at 20 (n = 485), 22 (n = 421) and 27 (n = 437) years and the fetal growth trajectory groups, adjusting for age, sex, adult lifestyle factors, and maternal factors during pregnancy. Results: Seven AC, five FL and five HC growth trajectory groups were identified. Compared to the average-stable (reference) group, a lower adult BMI was observed in two falling AC trajectories: (β = −1.45 kg/m2, 95% CI: −2.43 to −0.46, P = 0.004) and (β = −1.01 kg/m2, 95% CI: −1.96 to −0.05, P = 0.038). Conversely, higher adult BMI (2.58 kg/m2, 95% CI: 0.98 to 4.18, P = 0.002) and hs-CRP (37%, 95% CI: 9–73%, P = 0.008) were observed in a rising FL trajectory compared to the reference group. A high-stable HC trajectory associated with 20% lower adult hs-CRP (95% CI: 5–33%, P = 0.011). Conclusion: This study highlights the importance of understanding causes of the unique patterns of intrauterine growth. Different fetal growth trajectories from early pregnancy associate with subsequent adult adiposity and inflammation, which predispose to the risk of diabetes and cardiometabolic disease.
Original language | English |
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Pages (from-to) | 1925-1935 |
Number of pages | 11 |
Journal | International Journal of Obesity |
Volume | 46 |
Issue number | 10 |
DOIs | |
Publication status | Published - Oct 2022 |
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Dive into the research topics of 'Relationships between intrauterine fetal growth trajectories and markers of adiposity and inflammation in young adults'. Together they form a unique fingerprint.Projects
- 3 Finished
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Genetic And Early Life Predictors Of Ectopic Fat And Their Association With Cardiometabolic Health And Disease
Mori, T. (Investigator 01), Beilin, L. (Investigator 02), Moses, E. (Investigator 03), Watts, G. (Investigator 04) & Adams, L. (Investigator 05)
NHMRC National Health and Medical Research Council
1/01/16 → 31/12/22
Project: Research
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Childhood Obesity & its Relationship to Adult Sleep Disordered Breathing
Eastwood, P. (Investigator 01), Hillman, D. (Investigator 02), Smith, A. (Investigator 03), McArdle, N. (Investigator 04) & Huang, R.-C. (Investigator 05)
NHMRC National Health and Medical Research Council
1/01/12 → 31/12/14
Project: Research
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Predicting Asthma in Young Adults
Hall, G. (Investigator 01), Holt, P. (Investigator 02), Hollams, E. (Investigator 03) & Hantos, Z. (Investigator 04)
NHMRC National Health and Medical Research Council
1/01/12 → 31/12/14
Project: Research