Relationship of Human Immunodeficiency Virus Viral Load in Cerebrospinal Fluid and Plasma in Patients Co-infected With Cryptococcal Meningitis

Christina C. Chang; Richard  Kangethe; Saleha  Omarjee; Keshni  Hiramen; Bernadett  Gosnell; Katlego  Sojane; Mohamed-Yunus S.  Moosa; Sharon R.  Lewin; Martyn French; Thumbi  Ndung’u

doi:10.1093/ofid/ofx032

Relationship of Human Immunodeficiency Virus Viral Load in Cerebrospinal Fluid and Plasma in Patients Co-infected With Cryptococcal Meningitis

Christina C. Chang, Richard Kangethe, Saleha Omarjee, Keshni Hiramen, Bernadett Gosnell, Katlego Sojane, Mohamed-Yunus S. Moosa, Sharon R. Lewin, Martyn French, Thumbi Ndung’u

Research output: Contribution to journal › Article › peer-review

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Abstract

We measured human immunodeficiency virus (HIV) ribonucleic acid (RNA) in paired cerebrospinal fluid (CSF) and plasma samples in a prospective study of 91 HIV-infected, antiretroviral therapy-naive patients with cryptococcal meningitis. Cerebrospinal fluid HIV RNA was lower than in plasma (median 4.7 vs 5.2 log10 copies/mL, P < .0001) and positively correlated with plasma HIV RNA, peripheral CD4+ T-cell percentage, and CSF CXCL10. Plasma/CSF ratio of HIV RNA ranged widely from 0.2 to 265.5 with a median of 2.6. Cerebrospinal fluid quantitative cryptococcal culture positively correlated with CSF CCL2 and CCL3. CSF-plasma viral discordance was not associated with cryptococcal-associated immune reconstitution inflammatory syndrome.

Original language	English
Article number	ofx032
Pages (from-to)	1-5
Journal	Open Forum Infectious Diseases
Volume	4
Issue number	2
DOIs	https://doi.org/10.1093/ofid/ofx032
Publication status	Published - 1 Mar 2017

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10.1093/ofid/ofx032

HIV & HCV Vaccines and Immunopathogenesis
French, M. (Investigator 01)
NHMRC National Health and Medical Research Council
31/12/08 → 31/12/13
Project: Research

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Chang, C. C., Kangethe, R., Omarjee, S., Hiramen, K., Gosnell, B., Sojane, K., Moosa, M.-Y. S. ., Lewin, S. R. ., French, M., & Ndung’u, T. (2017). Relationship of Human Immunodeficiency Virus Viral Load in Cerebrospinal Fluid and Plasma in Patients Co-infected With Cryptococcal Meningitis. Open Forum Infectious Diseases, 4(2), 1-5. Article ofx032. https://doi.org/10.1093/ofid/ofx032

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title = "Relationship of Human Immunodeficiency Virus Viral Load in Cerebrospinal Fluid and Plasma in Patients Co-infected With Cryptococcal Meningitis",

abstract = "We measured human immunodeficiency virus (HIV) ribonucleic acid (RNA) in paired cerebrospinal fluid (CSF) and plasma samples in a prospective study of 91 HIV-infected, antiretroviral therapy-naive patients with cryptococcal meningitis. Cerebrospinal fluid HIV RNA was lower than in plasma (median 4.7 vs 5.2 log10 copies/mL, P < .0001) and positively correlated with plasma HIV RNA, peripheral CD4+ T-cell percentage, and CSF CXCL10. Plasma/CSF ratio of HIV RNA ranged widely from 0.2 to 265.5 with a median of 2.6. Cerebrospinal fluid quantitative cryptococcal culture positively correlated with CSF CCL2 and CCL3. CSF-plasma viral discordance was not associated with cryptococcal-associated immune reconstitution inflammatory syndrome.",

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Chang, CC, Kangethe, R, Omarjee, S, Hiramen, K, Gosnell, B, Sojane, K, Moosa, M-YS, Lewin, SR, French, M & Ndung’u, T 2017, 'Relationship of Human Immunodeficiency Virus Viral Load in Cerebrospinal Fluid and Plasma in Patients Co-infected With Cryptococcal Meningitis', Open Forum Infectious Diseases, vol. 4, no. 2, ofx032, pp. 1-5. https://doi.org/10.1093/ofid/ofx032

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AU - Chang, Christina C.

AU - Kangethe, Richard

AU - Omarjee, Saleha

AU - Hiramen, Keshni

AU - Gosnell, Bernadett

AU - Sojane, Katlego

AU - Moosa, Mohamed-Yunus S.

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AU - French, Martyn

AU - Ndung’u, Thumbi

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AB - We measured human immunodeficiency virus (HIV) ribonucleic acid (RNA) in paired cerebrospinal fluid (CSF) and plasma samples in a prospective study of 91 HIV-infected, antiretroviral therapy-naive patients with cryptococcal meningitis. Cerebrospinal fluid HIV RNA was lower than in plasma (median 4.7 vs 5.2 log10 copies/mL, P < .0001) and positively correlated with plasma HIV RNA, peripheral CD4+ T-cell percentage, and CSF CXCL10. Plasma/CSF ratio of HIV RNA ranged widely from 0.2 to 265.5 with a median of 2.6. Cerebrospinal fluid quantitative cryptococcal culture positively correlated with CSF CCL2 and CCL3. CSF-plasma viral discordance was not associated with cryptococcal-associated immune reconstitution inflammatory syndrome.

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DO - 10.1093/ofid/ofx032

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JO - Open Forum Infectious Diseases

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IS - 2

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Relationship of Human Immunodeficiency Virus Viral Load in Cerebrospinal Fluid and Plasma in Patients Co-infected With Cryptococcal Meningitis

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HIV & HCV Vaccines and Immunopathogenesis

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