Relationship Between Vitamin D Status From Childhood to Early Adulthood With Body Composition in Young Australian Adults

Kun Zhu, Wendy H. Oddy, Patrick Holt, Wendy Chan She Ping-Delfos, Joanne McVeigh, Leon Straker, Trevor A. Mori, Stephen Lye, Craig Pennell, John P. Walsh

Research output: Contribution to journalArticle

Abstract

Context: Vitamin D plays a role in the differentiation and metabolism of skeletal muscle and, possibly, adipose tissue; however, the relationship between vitamin D status during growth and body composition in early adulthood is unclear.

Objective: We examined associations between vitamin D status in childhood, adolescence, and early adulthood with body composition at age 20 years.

Design, Setting, Participants: We studied 821 offspring (385 females) of the Western Australian Pregnancy Cohort Study who had >= 3 serum 25-hydroxyvitamin D[25(OH) D] at age 6, 14, 17, and 20 years and body composition assessed at age 20 using dual-energy x-ray absorptiometry. The participants were grouped into four vitamin D status trajectories: consistently lower, decreasing, increasing, and consistently higher.

Results: The mean serum 25(OH) D at the study visits was 72.7 to 86.8 nmol/L. In males, serum 25(OH) D at 17 and 20 years was positively associated with lean body mass (LBM), and 25(OH) D at age 20 correlated negatively with fat body mass (FBM). Males with a consistently higher 25(OH) D trajectory had a 2.3-to 3.7-kg greater LBM and 4.1-to 6.0-kg lower FBM at 20 years compared with those with consistently lower or decreasing trajectories (P <0.05 for all). In females, 25(OH) D at 14, 17, and 20 years was negatively associated with FBM. Females with increasing or consistently higher 25(OH) D trajectories had a 5.2- to 6.8-kg lower FBM at age 20 compared with those with a consistently lower trajectory (P <0.05 for all).

Conclusions: In the present predominantly white, relatively vitamin D-replete cohort, a higher vitamin D status trajectory from childhood to early adulthood was associated with a greater LBM in males and lower FBM in both sexes at age 20. Copyright (C) 2019 Endocrine Society

Original languageEnglish
Pages (from-to)563-576
Number of pages14
JournalJournal of the Endocrine Society
Volume3
Issue number3
DOIs
Publication statusPublished - Mar 2019

Cite this

Zhu, Kun ; Oddy, Wendy H. ; Holt, Patrick ; Ping-Delfos, Wendy Chan She ; McVeigh, Joanne ; Straker, Leon ; Mori, Trevor A. ; Lye, Stephen ; Pennell, Craig ; Walsh, John P. / Relationship Between Vitamin D Status From Childhood to Early Adulthood With Body Composition in Young Australian Adults. In: Journal of the Endocrine Society. 2019 ; Vol. 3, No. 3. pp. 563-576.
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title = "Relationship Between Vitamin D Status From Childhood to Early Adulthood With Body Composition in Young Australian Adults",
abstract = "Context: Vitamin D plays a role in the differentiation and metabolism of skeletal muscle and, possibly, adipose tissue; however, the relationship between vitamin D status during growth and body composition in early adulthood is unclear.Objective: We examined associations between vitamin D status in childhood, adolescence, and early adulthood with body composition at age 20 years.Design, Setting, Participants: We studied 821 offspring (385 females) of the Western Australian Pregnancy Cohort Study who had >= 3 serum 25-hydroxyvitamin D[25(OH) D] at age 6, 14, 17, and 20 years and body composition assessed at age 20 using dual-energy x-ray absorptiometry. The participants were grouped into four vitamin D status trajectories: consistently lower, decreasing, increasing, and consistently higher.Results: The mean serum 25(OH) D at the study visits was 72.7 to 86.8 nmol/L. In males, serum 25(OH) D at 17 and 20 years was positively associated with lean body mass (LBM), and 25(OH) D at age 20 correlated negatively with fat body mass (FBM). Males with a consistently higher 25(OH) D trajectory had a 2.3-to 3.7-kg greater LBM and 4.1-to 6.0-kg lower FBM at 20 years compared with those with consistently lower or decreasing trajectories (P <0.05 for all). In females, 25(OH) D at 14, 17, and 20 years was negatively associated with FBM. Females with increasing or consistently higher 25(OH) D trajectories had a 5.2- to 6.8-kg lower FBM at age 20 compared with those with a consistently lower trajectory (P <0.05 for all).Conclusions: In the present predominantly white, relatively vitamin D-replete cohort, a higher vitamin D status trajectory from childhood to early adulthood was associated with a greater LBM in males and lower FBM in both sexes at age 20. Copyright (C) 2019 Endocrine Society",
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author = "Kun Zhu and Oddy, {Wendy H.} and Patrick Holt and Ping-Delfos, {Wendy Chan She} and Joanne McVeigh and Leon Straker and Mori, {Trevor A.} and Stephen Lye and Craig Pennell and Walsh, {John P.}",
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Relationship Between Vitamin D Status From Childhood to Early Adulthood With Body Composition in Young Australian Adults. / Zhu, Kun; Oddy, Wendy H.; Holt, Patrick; Ping-Delfos, Wendy Chan She; McVeigh, Joanne; Straker, Leon; Mori, Trevor A.; Lye, Stephen; Pennell, Craig; Walsh, John P.

In: Journal of the Endocrine Society, Vol. 3, No. 3, 03.2019, p. 563-576.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationship Between Vitamin D Status From Childhood to Early Adulthood With Body Composition in Young Australian Adults

AU - Zhu, Kun

AU - Oddy, Wendy H.

AU - Holt, Patrick

AU - Ping-Delfos, Wendy Chan She

AU - McVeigh, Joanne

AU - Straker, Leon

AU - Mori, Trevor A.

AU - Lye, Stephen

AU - Pennell, Craig

AU - Walsh, John P.

PY - 2019/3

Y1 - 2019/3

N2 - Context: Vitamin D plays a role in the differentiation and metabolism of skeletal muscle and, possibly, adipose tissue; however, the relationship between vitamin D status during growth and body composition in early adulthood is unclear.Objective: We examined associations between vitamin D status in childhood, adolescence, and early adulthood with body composition at age 20 years.Design, Setting, Participants: We studied 821 offspring (385 females) of the Western Australian Pregnancy Cohort Study who had >= 3 serum 25-hydroxyvitamin D[25(OH) D] at age 6, 14, 17, and 20 years and body composition assessed at age 20 using dual-energy x-ray absorptiometry. The participants were grouped into four vitamin D status trajectories: consistently lower, decreasing, increasing, and consistently higher.Results: The mean serum 25(OH) D at the study visits was 72.7 to 86.8 nmol/L. In males, serum 25(OH) D at 17 and 20 years was positively associated with lean body mass (LBM), and 25(OH) D at age 20 correlated negatively with fat body mass (FBM). Males with a consistently higher 25(OH) D trajectory had a 2.3-to 3.7-kg greater LBM and 4.1-to 6.0-kg lower FBM at 20 years compared with those with consistently lower or decreasing trajectories (P <0.05 for all). In females, 25(OH) D at 14, 17, and 20 years was negatively associated with FBM. Females with increasing or consistently higher 25(OH) D trajectories had a 5.2- to 6.8-kg lower FBM at age 20 compared with those with a consistently lower trajectory (P <0.05 for all).Conclusions: In the present predominantly white, relatively vitamin D-replete cohort, a higher vitamin D status trajectory from childhood to early adulthood was associated with a greater LBM in males and lower FBM in both sexes at age 20. Copyright (C) 2019 Endocrine Society

AB - Context: Vitamin D plays a role in the differentiation and metabolism of skeletal muscle and, possibly, adipose tissue; however, the relationship between vitamin D status during growth and body composition in early adulthood is unclear.Objective: We examined associations between vitamin D status in childhood, adolescence, and early adulthood with body composition at age 20 years.Design, Setting, Participants: We studied 821 offspring (385 females) of the Western Australian Pregnancy Cohort Study who had >= 3 serum 25-hydroxyvitamin D[25(OH) D] at age 6, 14, 17, and 20 years and body composition assessed at age 20 using dual-energy x-ray absorptiometry. The participants were grouped into four vitamin D status trajectories: consistently lower, decreasing, increasing, and consistently higher.Results: The mean serum 25(OH) D at the study visits was 72.7 to 86.8 nmol/L. In males, serum 25(OH) D at 17 and 20 years was positively associated with lean body mass (LBM), and 25(OH) D at age 20 correlated negatively with fat body mass (FBM). Males with a consistently higher 25(OH) D trajectory had a 2.3-to 3.7-kg greater LBM and 4.1-to 6.0-kg lower FBM at 20 years compared with those with consistently lower or decreasing trajectories (P <0.05 for all). In females, 25(OH) D at 14, 17, and 20 years was negatively associated with FBM. Females with increasing or consistently higher 25(OH) D trajectories had a 5.2- to 6.8-kg lower FBM at age 20 compared with those with a consistently lower trajectory (P <0.05 for all).Conclusions: In the present predominantly white, relatively vitamin D-replete cohort, a higher vitamin D status trajectory from childhood to early adulthood was associated with a greater LBM in males and lower FBM in both sexes at age 20. Copyright (C) 2019 Endocrine Society

KW - 25-hydroxyvitamin D

KW - body composition

KW - lean body mass

KW - fat body mass

KW - young adults

KW - Raine study

KW - D-RECEPTOR EXPRESSION

KW - SKELETAL-MUSCLE

KW - 1,25-DIHYDROXYVITAMIN D-3

KW - PARATHYROID-HORMONE

KW - RISK-FACTORS

KW - MASS INDEX

KW - FAT MASS

KW - WOMEN

KW - ASSOCIATION

KW - SUPPLEMENTATION

U2 - 10.1210/js.2018-00349

DO - 10.1210/js.2018-00349

M3 - Article

VL - 3

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EP - 576

JO - Journal of the Endocrine Society

JF - Journal of the Endocrine Society

SN - 2472-1972

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ER -