Projects per year
Context: Vitamin D plays a role in the differentiation and metabolism of skeletal muscle and, possibly, adipose tissue; however, the relationship between vitamin D status during growth and body composition in early adulthood is unclear.
Objective: We examined associations between vitamin D status in childhood, adolescence, and early adulthood with body composition at age 20 years.
Design, Setting, Participants: We studied 821 offspring (385 females) of the Western Australian Pregnancy Cohort Study who had >= 3 serum 25-hydroxyvitamin D[25(OH) D] at age 6, 14, 17, and 20 years and body composition assessed at age 20 using dual-energy x-ray absorptiometry. The participants were grouped into four vitamin D status trajectories: consistently lower, decreasing, increasing, and consistently higher.
Results: The mean serum 25(OH) D at the study visits was 72.7 to 86.8 nmol/L. In males, serum 25(OH) D at 17 and 20 years was positively associated with lean body mass (LBM), and 25(OH) D at age 20 correlated negatively with fat body mass (FBM). Males with a consistently higher 25(OH) D trajectory had a 2.3-to 3.7-kg greater LBM and 4.1-to 6.0-kg lower FBM at 20 years compared with those with consistently lower or decreasing trajectories (P <0.05 for all). In females, 25(OH) D at 14, 17, and 20 years was negatively associated with FBM. Females with increasing or consistently higher 25(OH) D trajectories had a 5.2- to 6.8-kg lower FBM at age 20 compared with those with a consistently lower trajectory (P <0.05 for all).
Conclusions: In the present predominantly white, relatively vitamin D-replete cohort, a higher vitamin D status trajectory from childhood to early adulthood was associated with a greater LBM in males and lower FBM in both sexes at age 20. Copyright (C) 2019 Endocrine Society
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- 5 Finished
Nutritional determinants of Cardiometabolic risk & mental health disorders from infancy to adulthood
1/01/12 → 31/12/14
403981: Childhood Precursors of Adult Cardiovascular Disease, Obesity and Diabetes- 16 Year Follow up of a Longitudinal Cohort
1/01/06 → 31/12/09