Relationship between umbilical cord sex hormone binding globulin, sex steroids, and age at menarche: a prospective cohort study

Martha Hickey, Lauren P. Lawson, Jennifer L. Marino, Jeffrey A. Keelan, Roger Hart

    Research output: Contribution to journalArticle

    Abstract

    Objective: To study the role of the prenatal environment in regulating reproductive development by measuring the prospective association between umbilical cord concentrations of sex hormone binding globulin (SHBG; principal regulator of sex steroid activity), bioavailable sex steroids, and age at menarche. Design: Prospective population-based cohort. Setting: Not applicable. Patient(s): In 286 female members of the Western Australian Pregnancy (Raine) cohort, concentrations of SHBG and steroids (estrogens: estrone, estradiol, estriol and estetrol [E4]; androgens: total testosterone, Δ4-androstenedione, androstenedione and dehydroepiandrosterone) were measured by liquid chromatography-tandem mass spectrometry from archived umbilical cord blood samples collected at birth. Bioavailable concentrations of testosterone and estradiol were calculated along with total composite measures of androgen and estrogen bioactivity. SHBG was measured by ELISA. Intervention(s): None. Main Outcome Measure(s): Age of menarche was calculated from date of menarche, collected prospectively by questionnaire sent home with participants at the year 10 follow-up. Result(s): Higher maternal education, higher body mass index, and the presence of antepartum hemorrhage were all significantly associated with earlier age at menarche. The bioavailable sex steroid measures accounted for 8.3% of the variance in age at menarche. Further, both SHBG and E4 concentrations accounted for a significant proportion of unique variance in age at menarche. Conclusion(s): Lower SHBG and higher E4 concentrations in umbilical cord blood were associated with earlier age at menarche. These results suggest that the prenatal sex steroid environment contributes toward pubertal development and age at menarche.

    Original languageEnglish
    Pages (from-to)965-973
    Number of pages9
    JournalFertility and Sterility
    Volume110
    Issue number5
    DOIs
    Publication statusPublished - 1 Oct 2018

    Fingerprint

    Sex Hormone-Binding Globulin
    Menarche
    Umbilical Cord
    Cohort Studies
    Steroids
    Prospective Studies
    Androstenedione
    Fetal Blood
    Androgens
    Estetrol
    Testosterone
    Estradiol
    Estrogens
    Estriol
    Dehydroepiandrosterone
    Estrone
    Tandem Mass Spectrometry
    Liquid Chromatography
    Body Mass Index
    Enzyme-Linked Immunosorbent Assay

    Cite this

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    title = "Relationship between umbilical cord sex hormone binding globulin, sex steroids, and age at menarche: a prospective cohort study",
    abstract = "Objective: To study the role of the prenatal environment in regulating reproductive development by measuring the prospective association between umbilical cord concentrations of sex hormone binding globulin (SHBG; principal regulator of sex steroid activity), bioavailable sex steroids, and age at menarche. Design: Prospective population-based cohort. Setting: Not applicable. Patient(s): In 286 female members of the Western Australian Pregnancy (Raine) cohort, concentrations of SHBG and steroids (estrogens: estrone, estradiol, estriol and estetrol [E4]; androgens: total testosterone, Δ4-androstenedione, androstenedione and dehydroepiandrosterone) were measured by liquid chromatography-tandem mass spectrometry from archived umbilical cord blood samples collected at birth. Bioavailable concentrations of testosterone and estradiol were calculated along with total composite measures of androgen and estrogen bioactivity. SHBG was measured by ELISA. Intervention(s): None. Main Outcome Measure(s): Age of menarche was calculated from date of menarche, collected prospectively by questionnaire sent home with participants at the year 10 follow-up. Result(s): Higher maternal education, higher body mass index, and the presence of antepartum hemorrhage were all significantly associated with earlier age at menarche. The bioavailable sex steroid measures accounted for 8.3{\%} of the variance in age at menarche. Further, both SHBG and E4 concentrations accounted for a significant proportion of unique variance in age at menarche. Conclusion(s): Lower SHBG and higher E4 concentrations in umbilical cord blood were associated with earlier age at menarche. These results suggest that the prenatal sex steroid environment contributes toward pubertal development and age at menarche.",
    keywords = "age at menarche, androgen, estrogen, sex hormone binding globulin, Sex steroids",
    author = "Martha Hickey and Lawson, {Lauren P.} and Marino, {Jennifer L.} and Keelan, {Jeffrey A.} and Roger Hart",
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    Relationship between umbilical cord sex hormone binding globulin, sex steroids, and age at menarche : a prospective cohort study. / Hickey, Martha; Lawson, Lauren P.; Marino, Jennifer L.; Keelan, Jeffrey A.; Hart, Roger.

    In: Fertility and Sterility, Vol. 110, No. 5, 01.10.2018, p. 965-973.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Relationship between umbilical cord sex hormone binding globulin, sex steroids, and age at menarche

    T2 - a prospective cohort study

    AU - Hickey, Martha

    AU - Lawson, Lauren P.

    AU - Marino, Jennifer L.

    AU - Keelan, Jeffrey A.

    AU - Hart, Roger

    PY - 2018/10/1

    Y1 - 2018/10/1

    N2 - Objective: To study the role of the prenatal environment in regulating reproductive development by measuring the prospective association between umbilical cord concentrations of sex hormone binding globulin (SHBG; principal regulator of sex steroid activity), bioavailable sex steroids, and age at menarche. Design: Prospective population-based cohort. Setting: Not applicable. Patient(s): In 286 female members of the Western Australian Pregnancy (Raine) cohort, concentrations of SHBG and steroids (estrogens: estrone, estradiol, estriol and estetrol [E4]; androgens: total testosterone, Δ4-androstenedione, androstenedione and dehydroepiandrosterone) were measured by liquid chromatography-tandem mass spectrometry from archived umbilical cord blood samples collected at birth. Bioavailable concentrations of testosterone and estradiol were calculated along with total composite measures of androgen and estrogen bioactivity. SHBG was measured by ELISA. Intervention(s): None. Main Outcome Measure(s): Age of menarche was calculated from date of menarche, collected prospectively by questionnaire sent home with participants at the year 10 follow-up. Result(s): Higher maternal education, higher body mass index, and the presence of antepartum hemorrhage were all significantly associated with earlier age at menarche. The bioavailable sex steroid measures accounted for 8.3% of the variance in age at menarche. Further, both SHBG and E4 concentrations accounted for a significant proportion of unique variance in age at menarche. Conclusion(s): Lower SHBG and higher E4 concentrations in umbilical cord blood were associated with earlier age at menarche. These results suggest that the prenatal sex steroid environment contributes toward pubertal development and age at menarche.

    AB - Objective: To study the role of the prenatal environment in regulating reproductive development by measuring the prospective association between umbilical cord concentrations of sex hormone binding globulin (SHBG; principal regulator of sex steroid activity), bioavailable sex steroids, and age at menarche. Design: Prospective population-based cohort. Setting: Not applicable. Patient(s): In 286 female members of the Western Australian Pregnancy (Raine) cohort, concentrations of SHBG and steroids (estrogens: estrone, estradiol, estriol and estetrol [E4]; androgens: total testosterone, Δ4-androstenedione, androstenedione and dehydroepiandrosterone) were measured by liquid chromatography-tandem mass spectrometry from archived umbilical cord blood samples collected at birth. Bioavailable concentrations of testosterone and estradiol were calculated along with total composite measures of androgen and estrogen bioactivity. SHBG was measured by ELISA. Intervention(s): None. Main Outcome Measure(s): Age of menarche was calculated from date of menarche, collected prospectively by questionnaire sent home with participants at the year 10 follow-up. Result(s): Higher maternal education, higher body mass index, and the presence of antepartum hemorrhage were all significantly associated with earlier age at menarche. The bioavailable sex steroid measures accounted for 8.3% of the variance in age at menarche. Further, both SHBG and E4 concentrations accounted for a significant proportion of unique variance in age at menarche. Conclusion(s): Lower SHBG and higher E4 concentrations in umbilical cord blood were associated with earlier age at menarche. These results suggest that the prenatal sex steroid environment contributes toward pubertal development and age at menarche.

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