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Abstract
Low-grade inflammation, endothelial dysfunction, and platelet hyper-reactivity
to agonists are associated with an increased risk of cardiovascular events. In
vitro and animal studies infer an inverse mechanistic relationship between platelet
activation and the production of endothelium-derived nitric oxide and
prostacyclin. This concept is supported by evidence of an inverse relationship
between endothelial function and platelet activation in high-risk cardiac
patients. The aim of this study was to investigate what relationship, if any, exists
between platelet and endothelial function in healthy, middle-aged, and elderly
adults. In 51 participants (18 male, 33 post menopausal female), endothelial
function was assessed by flow-mediated dilation (FMD). Platelet function was
assessed by flow cytometric determination of glycoprotein IIb/IIIa activation
(measured by PAC-1 binding), granule exocytosis (measured by surface P-selectin
expression), and monocyte-platelet aggregates (MPAs), with and without
stimulation by canonical platelet agonists adenosine diphosphate (ADP), arachidonic
acid (AA), and collagen. Correlation analysis indicated there was no significant
(all P => 0.05) relationship between FMD and any marker of in vivo
platelet activation (MPAs R = 0.193, PAC-1 R = 0.113, anti-CD62P
R = 0.078) or inducible platelet activation by ADP (MPA R = 0.128,
anti-CD62P R = 0.237), AA (MPA R = 0.122, PAC-1 R = 0.045, anti-
CD62P R = 0.142), or collagen (MPA R = 0.136, PAC-1 R = 0.174,
anti-CD62P R = 0.077). Our findings contrast with two previous studies
performed in high-risk cardiac patients, which reported inverse relationships
between platelet activation and endothelial function, suggesting that some compensatory
redundancy may exist in the relationship between platelet and
endothelial function in preclinical populations.
Original language | English |
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Article number | e13189 |
Number of pages | 10 |
Journal | Physiological Reports |
Volume | 5 |
Issue number | 10 |
DOIs | |
Publication status | Published - 22 May 2017 |
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Dive into the research topics of 'Relationship between monocyte-platelet aggregation and endothelial function in middle-aged and elderly adults'. Together they form a unique fingerprint.Projects
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Does Manipulation of Arterial Shear Stress Enhance Cerebrovascular Function and Cognition in the Aging Brain
Green, D. (Investigator 01), Lautenschlager, N. (Investigator 02), Cox, K. (Investigator 03), Badcock, J. (Investigator 04) & Pestell, C. (Investigator 05)
NHMRC National Health and Medical Research Council
1/01/13 → 31/12/16
Project: Research