Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: A cross-sectional, observational study

P.R. Gibson; C.J. Vaizey; C.M. Black; R. Nicholls; A.R. Weston; P.A. Bampton; M.P. Sparrow; Ian Lawrance; W.S. Selby; J.M. Andrews; A.J. Walsh; D.J. Hetzel; F.A. Macrae; G.T.C. Moore; M. Weltman; R. Leong; T. Fan

doi:10.1016/j.crohns.2013.11.017

Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: A cross-sectional, observational study

P.R. Gibson, C.J. Vaizey, C.M. Black, R. Nicholls, A.R. Weston, P.A. Bampton, M.P. Sparrow, Ian Lawrance, W.S. Selby, J.M. Andrews, A.J. Walsh, D.J. Hetzel, F.A. Macrae, G.T.C. Moore, M. Weltman, R. Leong, T. Fan

Research output: Contribution to journal › Article

64 Citations (Scopus)

Abstract

Background & aims: The burden of ulcerative colitis (UC) in relation to disease severity is not well documented. This study quantitatively evaluated the relationship between disease activity and quality of life (QoL), as well as health care utilization, cost, and work-related impairment associated with UC in an Australian population. Methods: A cross-sectional, noninterventional, observational study was performed in patients with a wide range of disease severity recruited during routine specialist consultations. Evaluations included the Assessment of Quality of Life-8-dimension (AQoL-8D), EuroQol 5-dimension, 5-level (EQ-5D-5L), the disease-specific Inflammatory Bowel Disease Questionnaire (IBDQ), and the Work Productivity and Activity Impairment (WPAI) instrument. The 3-item Partial Mayo Score was used to assess disease severity. Health care resource utilization was assessed by chart review and patient questionnaires. Results: In 175 patients, mean (SD) AQoL-8D and EQ-5D-5L scores were greater for patients in remission (0.80 [0.19] and 0.81 [0.18], respectively) than for patients with active disease (0.70 [0.20] and 0.72 [0.19], respectively, both Ps.

Original language	English
Pages (from-to)	598-606
Journal	Journal of Crohn's and Colitis
Volume	8
Issue number	7
DOIs	https://doi.org/10.1016/j.crohns.2013.11.017
Publication status	Published - 2014

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Gibson, P. R., Vaizey, C. J., Black, C. M., Nicholls, R., Weston, A. R., Bampton, P. A., Sparrow, M. P., Lawrance, I., Selby, W. S., Andrews, J. M., Walsh, A. J., Hetzel, D. J., Macrae, F. A., Moore, G. T. C., Weltman, M., Leong, R., & Fan, T. (2014). Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: A cross-sectional, observational study. Journal of Crohn's and Colitis, 8(7), 598-606. https://doi.org/10.1016/j.crohns.2013.11.017

Gibson, P.R. ; Vaizey, C.J. ; Black, C.M. ; Nicholls, R. ; Weston, A.R. ; Bampton, P.A. ; Sparrow, M.P. ; Lawrance, Ian ; Selby, W.S. ; Andrews, J.M. ; Walsh, A.J. ; Hetzel, D.J. ; Macrae, F.A. ; Moore, G.T.C. ; Weltman, M. ; Leong, R. ; Fan, T. / Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: A cross-sectional, observational study. In: Journal of Crohn's and Colitis. 2014 ; Vol. 8, No. 7. pp. 598-606.

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title = "Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: A cross-sectional, observational study",

abstract = "Background & aims: The burden of ulcerative colitis (UC) in relation to disease severity is not well documented. This study quantitatively evaluated the relationship between disease activity and quality of life (QoL), as well as health care utilization, cost, and work-related impairment associated with UC in an Australian population. Methods: A cross-sectional, noninterventional, observational study was performed in patients with a wide range of disease severity recruited during routine specialist consultations. Evaluations included the Assessment of Quality of Life-8-dimension (AQoL-8D), EuroQol 5-dimension, 5-level (EQ-5D-5L), the disease-specific Inflammatory Bowel Disease Questionnaire (IBDQ), and the Work Productivity and Activity Impairment (WPAI) instrument. The 3-item Partial Mayo Score was used to assess disease severity. Health care resource utilization was assessed by chart review and patient questionnaires. Results: In 175 patients, mean (SD) AQoL-8D and EQ-5D-5L scores were greater for patients in remission (0.80 [0.19] and 0.81 [0.18], respectively) than for patients with active disease (0.70 [0.20] and 0.72 [0.19], respectively, both Ps.",

author = "P.R. Gibson and C.J. Vaizey and C.M. Black and R. Nicholls and A.R. Weston and P.A. Bampton and M.P. Sparrow and Ian Lawrance and W.S. Selby and J.M. Andrews and A.J. Walsh and D.J. Hetzel and F.A. Macrae and G.T.C. Moore and M. Weltman and R. Leong and T. Fan",

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Gibson, PR, Vaizey, CJ, Black, CM, Nicholls, R, Weston, AR, Bampton, PA, Sparrow, MP, Lawrance, I, Selby, WS, Andrews, JM, Walsh, AJ, Hetzel, DJ, Macrae, FA, Moore, GTC, Weltman, M, Leong, R & Fan, T 2014, 'Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: A cross-sectional, observational study', Journal of Crohn's and Colitis, vol. 8, no. 7, pp. 598-606. https://doi.org/10.1016/j.crohns.2013.11.017

Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: A cross-sectional, observational study. / Gibson, P.R.; Vaizey, C.J.; Black, C.M.; Nicholls, R.; Weston, A.R.; Bampton, P.A.; Sparrow, M.P.; Lawrance, Ian; Selby, W.S.; Andrews, J.M.; Walsh, A.J.; Hetzel, D.J.; Macrae, F.A.; Moore, G.T.C.; Weltman, M.; Leong, R.; Fan, T.

In: Journal of Crohn's and Colitis, Vol. 8, No. 7, 2014, p. 598-606.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: A cross-sectional, observational study

AU - Gibson, P.R.

AU - Vaizey, C.J.

AU - Black, C.M.

AU - Nicholls, R.

AU - Weston, A.R.

AU - Bampton, P.A.

AU - Sparrow, M.P.

AU - Lawrance, Ian

AU - Selby, W.S.

AU - Andrews, J.M.

AU - Walsh, A.J.

AU - Hetzel, D.J.

AU - Macrae, F.A.

AU - Moore, G.T.C.

AU - Weltman, M.

AU - Leong, R.

AU - Fan, T.

PY - 2014

Y1 - 2014

N2 - Background & aims: The burden of ulcerative colitis (UC) in relation to disease severity is not well documented. This study quantitatively evaluated the relationship between disease activity and quality of life (QoL), as well as health care utilization, cost, and work-related impairment associated with UC in an Australian population. Methods: A cross-sectional, noninterventional, observational study was performed in patients with a wide range of disease severity recruited during routine specialist consultations. Evaluations included the Assessment of Quality of Life-8-dimension (AQoL-8D), EuroQol 5-dimension, 5-level (EQ-5D-5L), the disease-specific Inflammatory Bowel Disease Questionnaire (IBDQ), and the Work Productivity and Activity Impairment (WPAI) instrument. The 3-item Partial Mayo Score was used to assess disease severity. Health care resource utilization was assessed by chart review and patient questionnaires. Results: In 175 patients, mean (SD) AQoL-8D and EQ-5D-5L scores were greater for patients in remission (0.80 [0.19] and 0.81 [0.18], respectively) than for patients with active disease (0.70 [0.20] and 0.72 [0.19], respectively, both Ps.

AB - Background & aims: The burden of ulcerative colitis (UC) in relation to disease severity is not well documented. This study quantitatively evaluated the relationship between disease activity and quality of life (QoL), as well as health care utilization, cost, and work-related impairment associated with UC in an Australian population. Methods: A cross-sectional, noninterventional, observational study was performed in patients with a wide range of disease severity recruited during routine specialist consultations. Evaluations included the Assessment of Quality of Life-8-dimension (AQoL-8D), EuroQol 5-dimension, 5-level (EQ-5D-5L), the disease-specific Inflammatory Bowel Disease Questionnaire (IBDQ), and the Work Productivity and Activity Impairment (WPAI) instrument. The 3-item Partial Mayo Score was used to assess disease severity. Health care resource utilization was assessed by chart review and patient questionnaires. Results: In 175 patients, mean (SD) AQoL-8D and EQ-5D-5L scores were greater for patients in remission (0.80 [0.19] and 0.81 [0.18], respectively) than for patients with active disease (0.70 [0.20] and 0.72 [0.19], respectively, both Ps.

U2 - 10.1016/j.crohns.2013.11.017

DO - 10.1016/j.crohns.2013.11.017

M3 - Article

C2 - 24345767

VL - 8

SP - 598

EP - 606

JO - JOURNAL OF CROHNS & COLITIS

JF - JOURNAL OF CROHNS & COLITIS

SN - 1873-9946

IS - 7

ER -