Relationship between chronic kidney disease and cerebral white matter hyperintensities: a systematic review

Federico Greco, Luigi Giuseppe Quarta, Paul M. Parizel, Bruno Beomonte Zobel, Carlo Cosimo Quattrocchi, Carlo Augusto Mallio

Research output: Contribution to journalReview articlepeer-review


Background: This systematic review summarizes available evidence on the relationship between white matter hyperintensities (WMH) volumetric quantification on brain MRI scans and chronic kidney disease (CKD).Methods: The literature search was performed in March 2022 using MEDLINE PubMed Central, Scopus and Web of Science - Publons as search engines. Relevant articles investigating, with a quantitative volumetric approach, the link between WMH and CKD patients were selected.Results: The database search strategy found 987 articles, after excluding duplicates, the titles and abstracts of the remaining 320 articles were examined. Subsequently 276 articles were excluded as they were not relevant to the topic. Of the 44 articles evaluated for eligibility, 36 were excluded because the quantitative analysis of WMH was not volumetric. Finally, 8 articles were included in this systematic review.Conclusions: Literature on this topic is extremely heterogeneous in terms of methodology and samples. However, evidence shows that there is a relationship between CKD and WMH volume of the brain. We recommend that quantifiable biomarkers such as estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (UACR) should be included in studies dealing with cerebrovascular disease. The biological and molecular mechanisms underlying cerebrovascular damage in patients with chronic renal failure deserve to be further explored.

Original languageEnglish
Pages (from-to)7596-7606
Number of pages11
JournalQuantitative Imaging in Medicine and Surgery
Issue number11
Early online date2 Jan 2023
Publication statusPublished - Nov 2023


Dive into the research topics of 'Relationship between chronic kidney disease and cerebral white matter hyperintensities: a systematic review'. Together they form a unique fingerprint.

Cite this