Relating excitatory and inhibitory neurochemicals to visual perception: A magnetic resonance study of occipital cortex between migraine events

Yu Man Chan, Kabilan Pitchaimuthu, Qi Zhu Wu, Olivia L. Carter, Gary F. Egan, David R. Badcock, Allison M. McKendrick

Research output: Contribution to journalArticle

Abstract

Certain perceptual measures have been proposed as indirect assays of brain neurochemical status in people with migraine. One such measure is binocular rivalry, however, previous studies have not measured rivalry characteristics and brain neurochemistry together in people with migraine. This study compared spectroscopy-measured levels of GABA and Glx (glutamine and glutamate complex) in visual cortex between 16 people with migraine and 16 non-headache controls, and assessed whether the concentration of these neurochemicals explains, at least partially, inter-individual variability in binocular rivalry perceptual measures. Mean Glx level was significantly reduced in migraineurs relative to controls, whereas mean occipital GABA levels were similar between groups. Neither GABA levels, nor Glx levels correlated with rivalry percept duration. Our results thus suggest that the previously suggested relationship between rivalry percept duration and GABAergic inhibitory neurotransmitter concentration in visual cortex is not strong enough to enable rivalry percept duration to be reliably assumed to be a surrogate for GABA concentration, at least in the context of healthy individuals and those that experience migraine.

Original languageEnglish
Article numbere0208666
JournalPLoS One
Volume14
Issue number7
DOIs
Publication statusPublished - 10 Jul 2019

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migraine
Occipital Lobe
Visual Perception
gamma-aminobutyric acid
Magnetic resonance
Migraine Disorders
gamma-Aminobutyric Acid
cortex
Magnetic Resonance Spectroscopy
Binoculars
Visual Cortex
duration
Brain
Neurochemistry
brain
neurotransmitters
Glutamine
glutamine
glutamates
Neurotransmitter Agents

Cite this

Chan, Yu Man ; Pitchaimuthu, Kabilan ; Wu, Qi Zhu ; Carter, Olivia L. ; Egan, Gary F. ; Badcock, David R. ; McKendrick, Allison M. / Relating excitatory and inhibitory neurochemicals to visual perception : A magnetic resonance study of occipital cortex between migraine events. In: PLoS One. 2019 ; Vol. 14, No. 7.
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Relating excitatory and inhibitory neurochemicals to visual perception : A magnetic resonance study of occipital cortex between migraine events. / Chan, Yu Man; Pitchaimuthu, Kabilan; Wu, Qi Zhu; Carter, Olivia L.; Egan, Gary F.; Badcock, David R.; McKendrick, Allison M.

In: PLoS One, Vol. 14, No. 7, e0208666, 10.07.2019.

Research output: Contribution to journalArticle

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