Regulation of translational fidelity in mitochondrial and nuclear genomes

Danielle Rudler

doi:10.26182/6csm-dw91

Regulation of translational fidelity in mitochondrial and nuclear genomes

Danielle Rudler

Research output: Thesis › Doctoral Thesis

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Abstract

The genetic information contained in DNA must be read correctly into messenger RNA before functional proteins can be produced. Eukaryotes contain two spatially separated genomes, contained within the nucleus and the mitochondria, and the expression of both genomes is necessary for energy production and mitochondrial function. In this thesis, I have investigated the roles of translation initiation, RNA processing and the regulation of tRNA abundance on fidelity in these genomes and highlight the mechanisms regulating translational fidelity that ensure coordinated protein production in eukaryotic cells.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Filipovska, Aleksandra, Supervisor Richman, Tara, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	21 Apr 2022
DOIs	https://doi.org/10.26182/6csm-dw91
Publication status	Unpublished - 2021

Embargo information

Embargoed from 04/05/2022 to 21/04/2024. Became publicly available on 21/04/2024.

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10.26182/6csm-dw91

THESIS - DOCTOR OF PHILOSOPHY - RUDLER, Danielle Louise - 2022 - Part 1
THESIS - DOCTOR OF PHILOSOPHY - RUDLER, Danielle Louise - 2022 - Part 2
THESIS - DOCTOR OF PHILOSOPHY - RUDLER, Danielle Louise - 2022 - Part 3
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Cite this

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AB - The genetic information contained in DNA must be read correctly into messenger RNA before functional proteins can be produced. Eukaryotes contain two spatially separated genomes, contained within the nucleus and the mitochondria, and the expression of both genomes is necessary for energy production and mitochondrial function. In this thesis, I have investigated the roles of translation initiation, RNA processing and the regulation of tRNA abundance on fidelity in these genomes and highlight the mechanisms regulating translational fidelity that ensure coordinated protein production in eukaryotic cells.

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DO - 10.26182/6csm-dw91

M3 - Doctoral Thesis

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Regulation of translational fidelity in mitochondrial and nuclear genomes

Abstract

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