Regulation of immune responses by E3 ubiquitin ligase Cbl-b

Rong Tang, Wallace Y. Langdon, Jian Zhang

Research output: Contribution to journalReview articlepeer-review

38 Citations (Scopus)
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Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, has been identified as a critical regulator of adaptive immune responses. Cbl-b is essential for establishing the threshold for T cell activation and regulating peripheral T cell tolerance through various mechanisms. Intriguingly, recent studies indicate that Cbl-b also modulates innate immune responses, and plays a key role in host defense to pathogens and anti-tumor immunity. These studies suggest that targeting Cbl-b may represent a potential therapeutic strategy for the management of human immune-related disorders such as autoimmune diseases, infections, tumors, and allergic airway inflammation. In this review, we summarize the latest developments regarding the roles of Cbl-b in innate and adaptive immunity, and immune-mediated diseases.

Original languageEnglish
Article number103878
JournalCellular Immunology
Publication statusPublished - Jun 2019


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