Regulation of immune responses by E3 ubiquitin ligase Cbl-b

Rong Tang; Wallace Y. Langdon; Jian Zhang

doi:10.1016/j.cellimm.2018.11.002

Regulation of immune responses by E3 ubiquitin ligase Cbl-b

Rong Tang, Wallace Y. Langdon, Jian Zhang

School of Biological Sciences

Research output: Contribution to journal › Review article › peer-review

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Abstract

Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, has been identified as a critical regulator of adaptive immune responses. Cbl-b is essential for establishing the threshold for T cell activation and regulating peripheral T cell tolerance through various mechanisms. Intriguingly, recent studies indicate that Cbl-b also modulates innate immune responses, and plays a key role in host defense to pathogens and anti-tumor immunity. These studies suggest that targeting Cbl-b may represent a potential therapeutic strategy for the management of human immune-related disorders such as autoimmune diseases, infections, tumors, and allergic airway inflammation. In this review, we summarize the latest developments regarding the roles of Cbl-b in innate and adaptive immunity, and immune-mediated diseases.

Original language	English
Article number	103878
Journal	Cellular Immunology
Volume	340
DOIs	https://doi.org/10.1016/j.cellimm.2018.11.002
Publication status	Published - Jun 2019

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10.1016/j.cellimm.2018.11.002

Tang et al., 2019 Regulation of immune responses by E3 ubiquitin ligase Cbl-bAccepted author manuscript, 1.61 MBLicence: CC BY-NC-ND

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title = "Regulation of immune responses by E3 ubiquitin ligase Cbl-b",

abstract = "Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, has been identified as a critical regulator of adaptive immune responses. Cbl-b is essential for establishing the threshold for T cell activation and regulating peripheral T cell tolerance through various mechanisms. Intriguingly, recent studies indicate that Cbl-b also modulates innate immune responses, and plays a key role in host defense to pathogens and anti-tumor immunity. These studies suggest that targeting Cbl-b may represent a potential therapeutic strategy for the management of human immune-related disorders such as autoimmune diseases, infections, tumors, and allergic airway inflammation. In this review, we summarize the latest developments regarding the roles of Cbl-b in innate and adaptive immunity, and immune-mediated diseases.",

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author = "Rong Tang and Langdon, {Wallace Y.} and Jian Zhang",

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T1 - Regulation of immune responses by E3 ubiquitin ligase Cbl-b

AU - Tang, Rong

AU - Langdon, Wallace Y.

AU - Zhang, Jian

PY - 2019/6

Y1 - 2019/6

N2 - Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, has been identified as a critical regulator of adaptive immune responses. Cbl-b is essential for establishing the threshold for T cell activation and regulating peripheral T cell tolerance through various mechanisms. Intriguingly, recent studies indicate that Cbl-b also modulates innate immune responses, and plays a key role in host defense to pathogens and anti-tumor immunity. These studies suggest that targeting Cbl-b may represent a potential therapeutic strategy for the management of human immune-related disorders such as autoimmune diseases, infections, tumors, and allergic airway inflammation. In this review, we summarize the latest developments regarding the roles of Cbl-b in innate and adaptive immunity, and immune-mediated diseases.

AB - Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, has been identified as a critical regulator of adaptive immune responses. Cbl-b is essential for establishing the threshold for T cell activation and regulating peripheral T cell tolerance through various mechanisms. Intriguingly, recent studies indicate that Cbl-b also modulates innate immune responses, and plays a key role in host defense to pathogens and anti-tumor immunity. These studies suggest that targeting Cbl-b may represent a potential therapeutic strategy for the management of human immune-related disorders such as autoimmune diseases, infections, tumors, and allergic airway inflammation. In this review, we summarize the latest developments regarding the roles of Cbl-b in innate and adaptive immunity, and immune-mediated diseases.

KW - Cbl-b

KW - Immune-related disorders

KW - Innate and adaptive immune responses

KW - T cell tolerance

KW - Ubiquitination

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DO - 10.1016/j.cellimm.2018.11.002

M3 - Review article

AN - SCOPUS:85056260874

SN - 0008-8749

VL - 340

JO - Cellular Immunology

JF - Cellular Immunology

M1 - 103878

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Regulation of immune responses by E3 ubiquitin ligase Cbl-b

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