Regulation of Cytosolic and Mitochondrial Protein Synthesis in Health and Disease

Laetitia Hughes

doi:10.26182/t1a1-6z42

Regulation of Cytosolic and Mitochondrial Protein Synthesis in Health and Disease

Laetitia Hughes

School of Biomedical Sciences

Research output: Thesis › Doctoral Thesis

82 Downloads (Pure)

Abstract

Mammalian cells contain two genomes, localized in distinct cellular compartments, expressed by two separate translation systems. The nuclear genome encodes all of the genes required for cellular function, while the compact mitochondrial genome encodes several proteins essential to the energetic capacity of this organelle. The work presented in this thesis provides important insights into several mechanisms regulating mitochondrial and cytosolic translation, the coordination between these two systems, and how defects at protein synthesis can lead to disease.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Filipovska, Aleksandra, Supervisor Richman, Tara, Supervisor Hool, Livia, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	7 Jul 2022
DOIs	https://doi.org/10.26182/t1a1-6z42
Publication status	Unpublished - 2021

Embargo information

Embargoed from 96/10/2022 to 24/06/2024. Made publicly avaliable on 24/06/2024

Access to Document

10.26182/t1a1-6z42

A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance
Rossetti, G., Ermer, J. A., Stentenbach, M., Siira, S. J., Richman, T. R., Milenkovic, D., Perks, K. L., Hughes, L. A., Jamieson, E., Xiafukaiti, G., Ward, N. C., Takahashi, S., Gray, N., Viola, H. M., Hool, L. C., Rackham, O. & Filipovska, A., Sept 2021, In: Science Advances. 7, 39, eabi7514.
Research output: Contribution to journal › Article › peer-review

Open Access
15 Link opens in a new tab Citations (Scopus)
Fidelity and coordination of mitochondrial protein synthesis in health and disease
Rudler, D. L., Hughes, L. A., Viola, H. M., Hool, L. C., Rackham, O. & Filipovska, A., 15 Jul 2021, In: Journal of Physiology. 599, 14, p. 3449-3462 14 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
14 Link opens in a new tab Citations (Web of Science)
Fidelity of translation initiation is required for coordinated respiratory complex assembly
Rudler, D. L., Hughes, L. A., Perks, K. L., Richman, T. R., Kuznetsova, I., Ermer, J. A., Abudulai, L. N., Shearwood, A.-M. J., Viola, H. M., Hool, L. C., Siira, S. J., Rackham, O. & Filipovska, A., 20 Dec 2019, In: Science Advances. 5, 12, eaay2118.
Research output: Contribution to journal › Article › peer-review

Open Access
62 Link opens in a new tab Citations (Scopus)

Cite this

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title = "Regulation of Cytosolic and Mitochondrial Protein Synthesis in Health and Disease",

abstract = "Mammalian cells contain two genomes, localized in distinct cellular compartments, expressed by two separate translation systems. The nuclear genome encodes all of the genes required for cellular function, while the compact mitochondrial genome encodes several proteins essential to the energetic capacity of this organelle. The work presented in this thesis provides important insights into several mechanisms regulating mitochondrial and cytosolic translation, the coordination between these two systems, and how defects at protein synthesis can lead to disease.",

keywords = "mitochondria, translation, transfer RNA, isodecoder",

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school = "The University of Western Australia",

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AB - Mammalian cells contain two genomes, localized in distinct cellular compartments, expressed by two separate translation systems. The nuclear genome encodes all of the genes required for cellular function, while the compact mitochondrial genome encodes several proteins essential to the energetic capacity of this organelle. The work presented in this thesis provides important insights into several mechanisms regulating mitochondrial and cytosolic translation, the coordination between these two systems, and how defects at protein synthesis can lead to disease.

KW - mitochondria

KW - translation

KW - transfer RNA

KW - isodecoder

U2 - 10.26182/t1a1-6z42

DO - 10.26182/t1a1-6z42

M3 - Doctoral Thesis

ER -

Regulation of Cytosolic and Mitochondrial Protein Synthesis in Health and Disease

Abstract

Embargo information

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Research output

A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance

Fidelity and coordination of mitochondrial protein synthesis in health and disease

Fidelity of translation initiation is required for coordinated respiratory complex assembly

Cite this