Regulation of Cytosolic and Mitochondrial Protein Synthesis in Health and Disease

Laetitia Hughes

Research output: ThesisDoctoral Thesis

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Abstract

Mammalian cells contain two genomes, localized in distinct cellular compartments, expressed by two separate translation systems. The nuclear genome encodes all of the genes required for cellular function, while the compact mitochondrial genome encodes several proteins essential to the energetic capacity of this organelle. The work presented in this thesis provides important insights into several mechanisms regulating mitochondrial and cytosolic translation, the coordination between these two systems, and how defects at protein synthesis can lead to disease.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Filipovska, Aleksandra, Supervisor
  • Richman, Tara, Supervisor
  • Hool, Livia, Supervisor
Thesis sponsors
Award date7 Jul 2022
DOIs
Publication statusUnpublished - 2021

Embargo information

  • Embargoed from 96/10/2022 to 24/06/2024. Made publicly avaliable on 24/06/2024

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