Regulation of C-type lectin receptor-mediated antifungal immunity

Juan Tang, Guoxin Lin, Wallace Y. Langdon, Lijian Tao, Jian Zhang

Research output: Contribution to journalReview articlepeer-review

67 Citations (Scopus)


Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and regulation of antifungal immunity. Ongoing experiments over the last decade have elicited diverse CLR functions and novel regulatory mechanisms of CLR-mediated-signaling pathways. In this review, we highlight novel insights in antifungal innate and adaptive-protective immunity mediated by CLRs and discuss the potential therapeutic strategies against fungal infection based on targeting the mediators in the host immune system.

Original languageEnglish
Article number123
Number of pages12
JournalFrontiers in Immunology
Publication statusPublished - 1 Feb 2018


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