Regulation of C-type lectin receptor-mediated antifungal immunity

Juan Tang, Guoxin Lin, Wallace Y. Langdon, Lijian Tao, Jian Zhang

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and regulation of antifungal immunity. Ongoing experiments over the last decade have elicited diverse CLR functions and novel regulatory mechanisms of CLR-mediated-signaling pathways. In this review, we highlight novel insights in antifungal innate and adaptive-protective immunity mediated by CLRs and discuss the potential therapeutic strategies against fungal infection based on targeting the mediators in the host immune system.

Original languageEnglish
Article number123
Number of pages12
JournalFrontiers in Immunology
Volume9
DOIs
Publication statusPublished - 1 Feb 2018

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C-Type Lectins
Immunity
Mycoses
Adaptive Immunity
Immune System
Therapeutics

Cite this

Tang, Juan ; Lin, Guoxin ; Langdon, Wallace Y. ; Tao, Lijian ; Zhang, Jian. / Regulation of C-type lectin receptor-mediated antifungal immunity. In: Frontiers in Immunology. 2018 ; Vol. 9.
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Regulation of C-type lectin receptor-mediated antifungal immunity. / Tang, Juan; Lin, Guoxin; Langdon, Wallace Y.; Tao, Lijian; Zhang, Jian.

In: Frontiers in Immunology, Vol. 9, 123, 01.02.2018.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Regulation of C-type lectin receptor-mediated antifungal immunity

AU - Tang, Juan

AU - Lin, Guoxin

AU - Langdon, Wallace Y.

AU - Tao, Lijian

AU - Zhang, Jian

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and regulation of antifungal immunity. Ongoing experiments over the last decade have elicited diverse CLR functions and novel regulatory mechanisms of CLR-mediated-signaling pathways. In this review, we highlight novel insights in antifungal innate and adaptive-protective immunity mediated by CLRs and discuss the potential therapeutic strategies against fungal infection based on targeting the mediators in the host immune system.

AB - Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and regulation of antifungal immunity. Ongoing experiments over the last decade have elicited diverse CLR functions and novel regulatory mechanisms of CLR-mediated-signaling pathways. In this review, we highlight novel insights in antifungal innate and adaptive-protective immunity mediated by CLRs and discuss the potential therapeutic strategies against fungal infection based on targeting the mediators in the host immune system.

KW - C-type lectin receptor

KW - Fungal infection

KW - Immunity

KW - Posttranslational modifications

KW - Signaling pathways

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U2 - 10.3389/fimmu.2018.00123

DO - 10.3389/fimmu.2018.00123

M3 - Review article

VL - 9

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

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