Regulation of blood-brain barrier by a subset of astrocytes through mitochondrial transfer

Delin Liu

Research output: ThesisDoctoral Thesis

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Abstract

The blood-brain barrier (BBB) acts as the crucial protective structure in the central nervous system(CNS). Here we showed that a subset of astrocytes marked by Dmp1 expression transfer mitochondria to endothelial cells via their end feet for maintaining the integrity of BBB. Deletion of Mitofusion 2 (Mfn2) in Dmp1-expressing astrocytes inhibited the mitochondrial transfer and caused BBB leakage. Together, we describe a mechanism in which astrocytes regulate BBB integrity through mitochondrial transfer. Our findings provide new insights into the cellular framework that underpins progressive breakdown of BBB associated with aging and disease.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Zheng, Minghao, Supervisor
  • Gao, Junjie, Supervisor
Award date1 Jun 2023
DOIs
Publication statusUnpublished - 2023

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