Regular brief interruptions to sitting after a high-energy evening meal attenuate glycemic excursions in overweight/obese adults

R. E. Climie, M. S. Grace, R. L. Larsen, P. C. Dempsey, J. Oberoi, N. D. Cohen, N. Owen, B. A. Kingwell, D. W. Dunstan

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Abstract

Background and aims: Modern Western lifestyles are characterized by consumption of approximately 45% of total daily energy intake at the evening meal, followed by prolonged sitting while watching television (TV), which may deleteriously impact glycemic control. After a high-energy evening meal (dinner), we examined whether regular, brief activity bouts during TV commercial breaks could acutely lower postprandial glucose and insulin responses in overweight/obese adults, compared to prolonged uninterrupted sitting. Methods and results: Nine overweight/obese adults (29.7 ± 4.06 kg m−2; aged 32 ± 3 years; 5 male) completed two laboratory-based conditions of three and a half hours: prolonged sitting during TV viewing (SIT); and, prolonged sitting interrupted every 20 min with 3 min of light-intensity body-weight resistance activities (active commercial breaks; ACBs). Venous postprandial glucose and insulin responses to dinner were calculated as positive incremental area under the curve (iAUC) from baseline. Interstitial glucose was measured using a continuous glucose monitor and quantified as total AUC (tAUC). Compared to SIT, plasma glucose iAUC was reduced by 33% [3.4 ± 1.0 vs 5.1 ± 1.0 (mean ± SEM) mmol h·L−1, p = 0.019] and plasma insulin iAUC by 41% (813 ± 224 vs 1373 ± 224, p = 0.033 pmol h·L−1) for the ACB condition. During the ACB condition there was a significant reduction in interstitial glucose tAUC (24.4 ± 5.2 vs 26.9 ± 5.2 mmol h·L−1, p < 0.001), but this did not persist beyond the laboratory observation period. Conclusions: Regular brief light-intensity activity bouts can attenuate glycemic responses during television viewing time following a high-energy evening meal in overweight/obese adults.

Original languageEnglish
Pages (from-to)909-916
Number of pages8
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume28
Issue number9
DOIs
Publication statusPublished - 1 Sep 2018

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Meals
Area Under Curve
Television
Glucose
Insulin
Light
Energy Intake
Life Style
Body Weight
Observation

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Climie, R. E. ; Grace, M. S. ; Larsen, R. L. ; Dempsey, P. C. ; Oberoi, J. ; Cohen, N. D. ; Owen, N. ; Kingwell, B. A. ; Dunstan, D. W. / Regular brief interruptions to sitting after a high-energy evening meal attenuate glycemic excursions in overweight/obese adults. In: Nutrition, Metabolism and Cardiovascular Diseases. 2018 ; Vol. 28, No. 9. pp. 909-916.
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abstract = "Background and aims: Modern Western lifestyles are characterized by consumption of approximately 45{\%} of total daily energy intake at the evening meal, followed by prolonged sitting while watching television (TV), which may deleteriously impact glycemic control. After a high-energy evening meal (dinner), we examined whether regular, brief activity bouts during TV commercial breaks could acutely lower postprandial glucose and insulin responses in overweight/obese adults, compared to prolonged uninterrupted sitting. Methods and results: Nine overweight/obese adults (29.7 ± 4.06 kg m−2; aged 32 ± 3 years; 5 male) completed two laboratory-based conditions of three and a half hours: prolonged sitting during TV viewing (SIT); and, prolonged sitting interrupted every 20 min with 3 min of light-intensity body-weight resistance activities (active commercial breaks; ACBs). Venous postprandial glucose and insulin responses to dinner were calculated as positive incremental area under the curve (iAUC) from baseline. Interstitial glucose was measured using a continuous glucose monitor and quantified as total AUC (tAUC). Compared to SIT, plasma glucose iAUC was reduced by 33{\%} [3.4 ± 1.0 vs 5.1 ± 1.0 (mean ± SEM) mmol h·L−1, p = 0.019] and plasma insulin iAUC by 41{\%} (813 ± 224 vs 1373 ± 224, p = 0.033 pmol h·L−1) for the ACB condition. During the ACB condition there was a significant reduction in interstitial glucose tAUC (24.4 ± 5.2 vs 26.9 ± 5.2 mmol h·L−1, p < 0.001), but this did not persist beyond the laboratory observation period. Conclusions: Regular brief light-intensity activity bouts can attenuate glycemic responses during television viewing time following a high-energy evening meal in overweight/obese adults.",
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Regular brief interruptions to sitting after a high-energy evening meal attenuate glycemic excursions in overweight/obese adults. / Climie, R. E.; Grace, M. S.; Larsen, R. L.; Dempsey, P. C.; Oberoi, J.; Cohen, N. D.; Owen, N.; Kingwell, B. A.; Dunstan, D. W.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 28, No. 9, 01.09.2018, p. 909-916.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Regular brief interruptions to sitting after a high-energy evening meal attenuate glycemic excursions in overweight/obese adults

AU - Climie, R. E.

AU - Grace, M. S.

AU - Larsen, R. L.

AU - Dempsey, P. C.

AU - Oberoi, J.

AU - Cohen, N. D.

AU - Owen, N.

AU - Kingwell, B. A.

AU - Dunstan, D. W.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Background and aims: Modern Western lifestyles are characterized by consumption of approximately 45% of total daily energy intake at the evening meal, followed by prolonged sitting while watching television (TV), which may deleteriously impact glycemic control. After a high-energy evening meal (dinner), we examined whether regular, brief activity bouts during TV commercial breaks could acutely lower postprandial glucose and insulin responses in overweight/obese adults, compared to prolonged uninterrupted sitting. Methods and results: Nine overweight/obese adults (29.7 ± 4.06 kg m−2; aged 32 ± 3 years; 5 male) completed two laboratory-based conditions of three and a half hours: prolonged sitting during TV viewing (SIT); and, prolonged sitting interrupted every 20 min with 3 min of light-intensity body-weight resistance activities (active commercial breaks; ACBs). Venous postprandial glucose and insulin responses to dinner were calculated as positive incremental area under the curve (iAUC) from baseline. Interstitial glucose was measured using a continuous glucose monitor and quantified as total AUC (tAUC). Compared to SIT, plasma glucose iAUC was reduced by 33% [3.4 ± 1.0 vs 5.1 ± 1.0 (mean ± SEM) mmol h·L−1, p = 0.019] and plasma insulin iAUC by 41% (813 ± 224 vs 1373 ± 224, p = 0.033 pmol h·L−1) for the ACB condition. During the ACB condition there was a significant reduction in interstitial glucose tAUC (24.4 ± 5.2 vs 26.9 ± 5.2 mmol h·L−1, p < 0.001), but this did not persist beyond the laboratory observation period. Conclusions: Regular brief light-intensity activity bouts can attenuate glycemic responses during television viewing time following a high-energy evening meal in overweight/obese adults.

AB - Background and aims: Modern Western lifestyles are characterized by consumption of approximately 45% of total daily energy intake at the evening meal, followed by prolonged sitting while watching television (TV), which may deleteriously impact glycemic control. After a high-energy evening meal (dinner), we examined whether regular, brief activity bouts during TV commercial breaks could acutely lower postprandial glucose and insulin responses in overweight/obese adults, compared to prolonged uninterrupted sitting. Methods and results: Nine overweight/obese adults (29.7 ± 4.06 kg m−2; aged 32 ± 3 years; 5 male) completed two laboratory-based conditions of three and a half hours: prolonged sitting during TV viewing (SIT); and, prolonged sitting interrupted every 20 min with 3 min of light-intensity body-weight resistance activities (active commercial breaks; ACBs). Venous postprandial glucose and insulin responses to dinner were calculated as positive incremental area under the curve (iAUC) from baseline. Interstitial glucose was measured using a continuous glucose monitor and quantified as total AUC (tAUC). Compared to SIT, plasma glucose iAUC was reduced by 33% [3.4 ± 1.0 vs 5.1 ± 1.0 (mean ± SEM) mmol h·L−1, p = 0.019] and plasma insulin iAUC by 41% (813 ± 224 vs 1373 ± 224, p = 0.033 pmol h·L−1) for the ACB condition. During the ACB condition there was a significant reduction in interstitial glucose tAUC (24.4 ± 5.2 vs 26.9 ± 5.2 mmol h·L−1, p < 0.001), but this did not persist beyond the laboratory observation period. Conclusions: Regular brief light-intensity activity bouts can attenuate glycemic responses during television viewing time following a high-energy evening meal in overweight/obese adults.

KW - Circadian rhythm

KW - Glucose

KW - Obesity

KW - Sedentary

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